The first total synthesis and structural determination of TMC-66

Seijiro Hosokawa, Hitoshi Fumiyama, Hisato Fukuda, Tomohiro Fukuda, Masashi Seki, Kuniaki Tatsuta

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.

Original languageEnglish
Pages (from-to)7305-7308
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number41
DOIs
Publication statusPublished - 2007 Oct 8

Keywords

  • ECE inhibitor
  • Oxidative coupling
  • Structural determination
  • TMC-66
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Hosokawa, S., Fumiyama, H., Fukuda, H., Fukuda, T., Seki, M., & Tatsuta, K. (2007). The first total synthesis and structural determination of TMC-66. Tetrahedron Letters, 48(41), 7305-7308. https://doi.org/10.1016/j.tetlet.2007.08.037