The first total synthesis and structural determination of YCM1008A

Kuniaki Tatsuta, Takahiro Yamaguchi, Yusuke Tsuda, Yumiko Yamaguchi, Nobutaka Hattori, Hiroshi Nagai, Seijiro Hosokawa

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The first total synthesis and structural determination of YCM1008A, a Ca2+ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.

    Original languageEnglish
    Pages (from-to)4187-4190
    Number of pages4
    JournalTetrahedron Letters
    Volume48
    Issue number24
    DOIs
    Publication statusPublished - 2007 Jun 11

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    Pyridones
    YCM 1008A

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Tatsuta, K., Yamaguchi, T., Tsuda, Y., Yamaguchi, Y., Hattori, N., Nagai, H., & Hosokawa, S. (2007). The first total synthesis and structural determination of YCM1008A. Tetrahedron Letters, 48(24), 4187-4190. https://doi.org/10.1016/j.tetlet.2007.04.074

    The first total synthesis and structural determination of YCM1008A. / Tatsuta, Kuniaki; Yamaguchi, Takahiro; Tsuda, Yusuke; Yamaguchi, Yumiko; Hattori, Nobutaka; Nagai, Hiroshi; Hosokawa, Seijiro.

    In: Tetrahedron Letters, Vol. 48, No. 24, 11.06.2007, p. 4187-4190.

    Research output: Contribution to journalArticle

    Tatsuta, K, Yamaguchi, T, Tsuda, Y, Yamaguchi, Y, Hattori, N, Nagai, H & Hosokawa, S 2007, 'The first total synthesis and structural determination of YCM1008A', Tetrahedron Letters, vol. 48, no. 24, pp. 4187-4190. https://doi.org/10.1016/j.tetlet.2007.04.074
    Tatsuta K, Yamaguchi T, Tsuda Y, Yamaguchi Y, Hattori N, Nagai H et al. The first total synthesis and structural determination of YCM1008A. Tetrahedron Letters. 2007 Jun 11;48(24):4187-4190. https://doi.org/10.1016/j.tetlet.2007.04.074
    Tatsuta, Kuniaki ; Yamaguchi, Takahiro ; Tsuda, Yusuke ; Yamaguchi, Yumiko ; Hattori, Nobutaka ; Nagai, Hiroshi ; Hosokawa, Seijiro. / The first total synthesis and structural determination of YCM1008A. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 24. pp. 4187-4190.
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