The first total synthesis and structural determination of YCM1008A

Kuniaki Tatsuta; Takahiro Yamaguchi; Yusuke Tsuda; Yumiko Yamaguchi; Nobutaka Hattori; Hiroshi Nagai; Seijiro Hosokawa

doi:10.1016/j.tetlet.2007.04.074

The first total synthesis and structural determination of YCM1008A

Kuniaki Tatsuta, Takahiro Yamaguchi, Yusuke Tsuda, Yumiko Yamaguchi, Nobutaka Hattori, Hiroshi Nagai, Seijiro Hosokawa

School of Advanced Science and Engineering

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

The first total synthesis and structural determination of YCM1008A, a Ca²⁺ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.

Original language	English
Pages (from-to)	4187-4190
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	24
DOIs	https://doi.org/10.1016/j.tetlet.2007.04.074
Publication status	Published - 2007 Jun 11

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Tatsuta, K., Yamaguchi, T., Tsuda, Y., Yamaguchi, Y., Hattori, N., Nagai, H., & Hosokawa, S. (2007). The first total synthesis and structural determination of YCM1008A. Tetrahedron Letters, 48(24), 4187-4190. https://doi.org/10.1016/j.tetlet.2007.04.074

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AU - Tsuda, Yusuke

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AU - Hattori, Nobutaka

AU - Nagai, Hiroshi

AU - Hosokawa, Seijiro

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