The first total synthesis and structural determination of YCM1008A

Kuniaki Tatsuta; Takahiro Yamaguchi; Yusuke Tsuda; Yumiko Yamaguchi; Nobutaka Hattori; Hiroshi Nagai; Seijiro Hosokawa

doi:10.1016/j.tetlet.2007.04.074

The first total synthesis and structural determination of YCM1008A

Kuniaki Tatsuta, Takahiro Yamaguchi, Yusuke Tsuda, Yumiko Yamaguchi, Nobutaka Hattori, Hiroshi Nagai, Seijiro Hosokawa

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The first total synthesis and structural determination of YCM1008A, a Ca²⁺ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.

Original language	English
Pages (from-to)	4187-4190
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	24
DOIs	https://doi.org/10.1016/j.tetlet.2007.04.074
Publication status	Published - 2007 Jun 11

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "The first total synthesis and structural determination of YCM1008A",

abstract = "The first total synthesis and structural determination of YCM1008A, a Ca2+ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.",

author = "Kuniaki Tatsuta and Takahiro Yamaguchi and Yusuke Tsuda and Yumiko Yamaguchi and Nobutaka Hattori and Hiroshi Nagai and Seijiro Hosokawa",

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AU - Tatsuta, Kuniaki

AU - Yamaguchi, Takahiro

AU - Tsuda, Yusuke

AU - Yamaguchi, Yumiko

AU - Hattori, Nobutaka

AU - Nagai, Hiroshi

AU - Hosokawa, Seijiro

PY - 2007/6/11

Y1 - 2007/6/11

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AB - The first total synthesis and structural determination of YCM1008A, a Ca2+ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.

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