The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael-Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.
- Michael-Dieckmann type annulation
- Total synthesis
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry