The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Manami Oya, Tetsuya Kitaguchi, Ramona Pais, Frank Reimann, Fiona Gribble, Takashi Tsuboi

Research output: Contribution to journalArticle

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Abstract

Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

Original languageEnglish
Pages (from-to)4513-4521
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
Publication statusPublished - 2013 Feb 15

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Glucagon-Like Peptide 1
G-Protein-Coupled Receptors
Amino Acids
Enteroendocrine Cells
Ornithine
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. / Oya, Manami; Kitaguchi, Tetsuya; Pais, Ramona; Reimann, Frank; Gribble, Fiona; Tsuboi, Takashi.

In: Journal of Biological Chemistry, Vol. 288, No. 7, 15.02.2013, p. 4513-4521.

Research output: Contribution to journalArticle

Oya, Manami ; Kitaguchi, Tetsuya ; Pais, Ramona ; Reimann, Frank ; Gribble, Fiona ; Tsuboi, Takashi. / The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 7. pp. 4513-4521.
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