The gut microbiome of healthy Japanese and its microbial and functional uniqueness

Suguru Nishijima, Wataru Suda, Kenshiro Oshima, Seok Won Kim, Yuu Hirose, Hidetoshi Morita, Masahira Hattori

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Abstract

    The human gut microbiome has profound influences on the host's health largely through its interference with various intestinal functions. As recent studies have suggested diversity in the human gut microbiome among human populations, it will be interesting to analyse how gut microbiome is correlated with geographical, cultural, and traditional differences. The Japanese people are known to have several characteristic features such as eating a variety of traditional foods and exhibiting a low BMI and long life span. In this study, we analysed gut microbiomes of the Japanese by comparing the metagenomic data obtained from 106 Japanese individuals with those from 11 other nations. We found that the composition of the Japanese gut microbiome showed more abundant in the phylum Actinobacteria, in particular in the genus Bifidobacterium, than other nations. Regarding the microbial functions, those of carbohydrate metabolism were overrepresented with a concurrent decrease in those for replication and repair, and cell motility. The remarkable low prevalence of genes for methanogenesis with a significant depletion of the archaeon Methanobrevibacter smithii and enrichment of acetogenesis genes in the Japanese gut microbiome compared with others suggested a difference in the hydrogen metabolism pathway in the gut between them. It thus seems that the gut microbiome of the Japanese is considerably different from those of other populations, which cannot be simply explained by diet alone. We postulate possible existence of hitherto unknown factors contributing to the population-level diversity in human gut microbiomes.

    Original languageEnglish
    Pages (from-to)125-133
    Number of pages9
    JournalDNA Research
    Volume23
    Issue number2
    DOIs
    Publication statusPublished - 2016 Apr 1

    Fingerprint

    Microbiota
    Methanobrevibacter
    Population
    Metagenomics
    Bifidobacterium
    Gastrointestinal Microbiome
    Actinobacteria
    Archaea
    Carbohydrate Metabolism
    Genes
    Cell Movement
    Hydrogen
    Eating
    Diet
    Food
    Health

    Keywords

    • gut
    • Japanese
    • metagenome
    • microbiome

    ASJC Scopus subject areas

    • Genetics
    • Molecular Biology

    Cite this

    Nishijima, S., Suda, W., Oshima, K., Kim, S. W., Hirose, Y., Morita, H., & Hattori, M. (2016). The gut microbiome of healthy Japanese and its microbial and functional uniqueness. DNA Research, 23(2), 125-133. https://doi.org/10.1093/dnares/dsw002

    The gut microbiome of healthy Japanese and its microbial and functional uniqueness. / Nishijima, Suguru; Suda, Wataru; Oshima, Kenshiro; Kim, Seok Won; Hirose, Yuu; Morita, Hidetoshi; Hattori, Masahira.

    In: DNA Research, Vol. 23, No. 2, 01.04.2016, p. 125-133.

    Research output: Contribution to journalArticle

    Nishijima, S, Suda, W, Oshima, K, Kim, SW, Hirose, Y, Morita, H & Hattori, M 2016, 'The gut microbiome of healthy Japanese and its microbial and functional uniqueness', DNA Research, vol. 23, no. 2, pp. 125-133. https://doi.org/10.1093/dnares/dsw002
    Nishijima S, Suda W, Oshima K, Kim SW, Hirose Y, Morita H et al. The gut microbiome of healthy Japanese and its microbial and functional uniqueness. DNA Research. 2016 Apr 1;23(2):125-133. https://doi.org/10.1093/dnares/dsw002
    Nishijima, Suguru ; Suda, Wataru ; Oshima, Kenshiro ; Kim, Seok Won ; Hirose, Yuu ; Morita, Hidetoshi ; Hattori, Masahira. / The gut microbiome of healthy Japanese and its microbial and functional uniqueness. In: DNA Research. 2016 ; Vol. 23, No. 2. pp. 125-133.
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