The improved Jellyfish Valve: Durability enhancement with sufficient blood compatibility

Kiyotaka Iwasaki, Mitsuo Umezu, Yusuke Abe, Tsuneo Chinzei, Takashi Isoyama, Itsuro Saito, Mitsuhiko Ishimaru, Kou Imachi

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The Jellyfish Valve is one of the most promising polymer valves for artificial hearts. The present problems to be solved are 1) how to prevent a membrane fracture and 2) how to eliminate a calcification, because both of these problems were observed in experiments with goats after 312 days and 414 days of pumping. Finite element analysis demonstrated that mechanical tensile strain induced in the membrane at valve closure was clearly consistent with the fracture location as well as calcification area in in vivo experiments. Based on this finding, a new valve seat with an additional concentric ring 14 mm in diameter and 0.5 mm in width was finally developed. The maximum strain was dramatically reduced to 52% by the design improvement. Moreover, accelerated fatigue tests demonstrated that the improved valve was 10 times more durable as compared with the original valve, which was equivalent to an in vivo duration of 8.3 years. In animal experiments, including 31 days and 46 days use in a total artificial heart (TAH), no thrombus was found despite the lack of anticoagulant or antiplatelet therapies. These resuits indicate that the improved Jellyfish Valve might be one of the most durable polymer valves, able to perform in artificial hearts for a long period of time.

    Original languageEnglish
    Pages (from-to)532-537
    Number of pages6
    JournalASAIO Journal
    Volume48
    Issue number5
    Publication statusPublished - 2002 Sep

    Fingerprint

    Artificial heart
    Artificial Heart
    Durability
    Blood
    Polymers
    Membranes
    Finite Element Analysis
    Tensile strain
    Experiments
    Goats
    Anticoagulants
    Fatigue
    Animals
    Thrombosis
    Fatigue of materials
    Finite element method
    Therapeutics

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Iwasaki, K., Umezu, M., Abe, Y., Chinzei, T., Isoyama, T., Saito, I., ... Imachi, K. (2002). The improved Jellyfish Valve: Durability enhancement with sufficient blood compatibility. ASAIO Journal, 48(5), 532-537.

    The improved Jellyfish Valve : Durability enhancement with sufficient blood compatibility. / Iwasaki, Kiyotaka; Umezu, Mitsuo; Abe, Yusuke; Chinzei, Tsuneo; Isoyama, Takashi; Saito, Itsuro; Ishimaru, Mitsuhiko; Imachi, Kou.

    In: ASAIO Journal, Vol. 48, No. 5, 09.2002, p. 532-537.

    Research output: Contribution to journalArticle

    Iwasaki, K, Umezu, M, Abe, Y, Chinzei, T, Isoyama, T, Saito, I, Ishimaru, M & Imachi, K 2002, 'The improved Jellyfish Valve: Durability enhancement with sufficient blood compatibility', ASAIO Journal, vol. 48, no. 5, pp. 532-537.
    Iwasaki, Kiyotaka ; Umezu, Mitsuo ; Abe, Yusuke ; Chinzei, Tsuneo ; Isoyama, Takashi ; Saito, Itsuro ; Ishimaru, Mitsuhiko ; Imachi, Kou. / The improved Jellyfish Valve : Durability enhancement with sufficient blood compatibility. In: ASAIO Journal. 2002 ; Vol. 48, No. 5. pp. 532-537.
    @article{becc68af93184ef88121f62a22d361c6,
    title = "The improved Jellyfish Valve: Durability enhancement with sufficient blood compatibility",
    abstract = "The Jellyfish Valve is one of the most promising polymer valves for artificial hearts. The present problems to be solved are 1) how to prevent a membrane fracture and 2) how to eliminate a calcification, because both of these problems were observed in experiments with goats after 312 days and 414 days of pumping. Finite element analysis demonstrated that mechanical tensile strain induced in the membrane at valve closure was clearly consistent with the fracture location as well as calcification area in in vivo experiments. Based on this finding, a new valve seat with an additional concentric ring 14 mm in diameter and 0.5 mm in width was finally developed. The maximum strain was dramatically reduced to 52{\%} by the design improvement. Moreover, accelerated fatigue tests demonstrated that the improved valve was 10 times more durable as compared with the original valve, which was equivalent to an in vivo duration of 8.3 years. In animal experiments, including 31 days and 46 days use in a total artificial heart (TAH), no thrombus was found despite the lack of anticoagulant or antiplatelet therapies. These resuits indicate that the improved Jellyfish Valve might be one of the most durable polymer valves, able to perform in artificial hearts for a long period of time.",
    author = "Kiyotaka Iwasaki and Mitsuo Umezu and Yusuke Abe and Tsuneo Chinzei and Takashi Isoyama and Itsuro Saito and Mitsuhiko Ishimaru and Kou Imachi",
    year = "2002",
    month = "9",
    language = "English",
    volume = "48",
    pages = "532--537",
    journal = "ASAIO Journal",
    issn = "1058-2916",
    publisher = "Lippincott Williams and Wilkins",
    number = "5",

    }

    TY - JOUR

    T1 - The improved Jellyfish Valve

    T2 - Durability enhancement with sufficient blood compatibility

    AU - Iwasaki, Kiyotaka

    AU - Umezu, Mitsuo

    AU - Abe, Yusuke

    AU - Chinzei, Tsuneo

    AU - Isoyama, Takashi

    AU - Saito, Itsuro

    AU - Ishimaru, Mitsuhiko

    AU - Imachi, Kou

    PY - 2002/9

    Y1 - 2002/9

    N2 - The Jellyfish Valve is one of the most promising polymer valves for artificial hearts. The present problems to be solved are 1) how to prevent a membrane fracture and 2) how to eliminate a calcification, because both of these problems were observed in experiments with goats after 312 days and 414 days of pumping. Finite element analysis demonstrated that mechanical tensile strain induced in the membrane at valve closure was clearly consistent with the fracture location as well as calcification area in in vivo experiments. Based on this finding, a new valve seat with an additional concentric ring 14 mm in diameter and 0.5 mm in width was finally developed. The maximum strain was dramatically reduced to 52% by the design improvement. Moreover, accelerated fatigue tests demonstrated that the improved valve was 10 times more durable as compared with the original valve, which was equivalent to an in vivo duration of 8.3 years. In animal experiments, including 31 days and 46 days use in a total artificial heart (TAH), no thrombus was found despite the lack of anticoagulant or antiplatelet therapies. These resuits indicate that the improved Jellyfish Valve might be one of the most durable polymer valves, able to perform in artificial hearts for a long period of time.

    AB - The Jellyfish Valve is one of the most promising polymer valves for artificial hearts. The present problems to be solved are 1) how to prevent a membrane fracture and 2) how to eliminate a calcification, because both of these problems were observed in experiments with goats after 312 days and 414 days of pumping. Finite element analysis demonstrated that mechanical tensile strain induced in the membrane at valve closure was clearly consistent with the fracture location as well as calcification area in in vivo experiments. Based on this finding, a new valve seat with an additional concentric ring 14 mm in diameter and 0.5 mm in width was finally developed. The maximum strain was dramatically reduced to 52% by the design improvement. Moreover, accelerated fatigue tests demonstrated that the improved valve was 10 times more durable as compared with the original valve, which was equivalent to an in vivo duration of 8.3 years. In animal experiments, including 31 days and 46 days use in a total artificial heart (TAH), no thrombus was found despite the lack of anticoagulant or antiplatelet therapies. These resuits indicate that the improved Jellyfish Valve might be one of the most durable polymer valves, able to perform in artificial hearts for a long period of time.

    UR - http://www.scopus.com/inward/record.url?scp=0036738980&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0036738980&partnerID=8YFLogxK

    M3 - Article

    C2 - 12296575

    AN - SCOPUS:0036738980

    VL - 48

    SP - 532

    EP - 537

    JO - ASAIO Journal

    JF - ASAIO Journal

    SN - 1058-2916

    IS - 5

    ER -