The influence of passband limitation on the waveform of extracellular action potential

Takashi Mizuhiki, Kiyonori Inaba, Tsuyoshi Setogawa, Koji Toda, Shigeru Ozaki, Muneteka Shidara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The duration of the extracellular action potential (EAP) in single neuronal recording has often been used as a clue to infer biochemical, physiological or functional substrate of the recorded neurons, e.g. neurochemical type. However, when recording a neuronal activity, the high-pass filter is routinely used to achieve higher signal-to-noise ratio. Signal processing theory predicts that passband limitation stretches the waveform of discrete brief impulse. To examine whether the duration of filtered EAP could be the reliable measure, we investigated the influence of high-pass filter both by simulation and unfiltered unit recording data from monkey dorsal raphe. Consistent with the findings in recent theoretical study, the unfiltered EAPs displayed the sharp wave without following bumps. The duration of unfiltered EAP was not correlated with that of filtered EAP. Thus the duration of original EAP cannot be estimated from filtered EAP. It is needed to reexamine the EAP duration measured for classifying the neurons whose activities were recorded under the passband limitation in the related studies.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalNeuroscience Research
Volume72
Issue number3
DOIs
Publication statusPublished - 2012 Mar 1
Externally publishedYes

Fingerprint

Action Potentials
Neurons
Signal-To-Noise Ratio
Haplorhini
Theoretical Models

Keywords

  • Averaging
  • Extracellular action potential
  • Impulse response
  • Raphe nucleus
  • Waveform

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mizuhiki, T., Inaba, K., Setogawa, T., Toda, K., Ozaki, S., & Shidara, M. (2012). The influence of passband limitation on the waveform of extracellular action potential. Neuroscience Research, 72(3), 214-220. https://doi.org/10.1016/j.neures.2011.12.004

The influence of passband limitation on the waveform of extracellular action potential. / Mizuhiki, Takashi; Inaba, Kiyonori; Setogawa, Tsuyoshi; Toda, Koji; Ozaki, Shigeru; Shidara, Muneteka.

In: Neuroscience Research, Vol. 72, No. 3, 01.03.2012, p. 214-220.

Research output: Contribution to journalArticle

Mizuhiki, T, Inaba, K, Setogawa, T, Toda, K, Ozaki, S & Shidara, M 2012, 'The influence of passband limitation on the waveform of extracellular action potential', Neuroscience Research, vol. 72, no. 3, pp. 214-220. https://doi.org/10.1016/j.neures.2011.12.004
Mizuhiki, Takashi ; Inaba, Kiyonori ; Setogawa, Tsuyoshi ; Toda, Koji ; Ozaki, Shigeru ; Shidara, Muneteka. / The influence of passband limitation on the waveform of extracellular action potential. In: Neuroscience Research. 2012 ; Vol. 72, No. 3. pp. 214-220.
@article{90461a4e58b1420f82fb15a0350bc6cf,
title = "The influence of passband limitation on the waveform of extracellular action potential",
abstract = "The duration of the extracellular action potential (EAP) in single neuronal recording has often been used as a clue to infer biochemical, physiological or functional substrate of the recorded neurons, e.g. neurochemical type. However, when recording a neuronal activity, the high-pass filter is routinely used to achieve higher signal-to-noise ratio. Signal processing theory predicts that passband limitation stretches the waveform of discrete brief impulse. To examine whether the duration of filtered EAP could be the reliable measure, we investigated the influence of high-pass filter both by simulation and unfiltered unit recording data from monkey dorsal raphe. Consistent with the findings in recent theoretical study, the unfiltered EAPs displayed the sharp wave without following bumps. The duration of unfiltered EAP was not correlated with that of filtered EAP. Thus the duration of original EAP cannot be estimated from filtered EAP. It is needed to reexamine the EAP duration measured for classifying the neurons whose activities were recorded under the passband limitation in the related studies.",
keywords = "Averaging, Extracellular action potential, Impulse response, Raphe nucleus, Waveform",
author = "Takashi Mizuhiki and Kiyonori Inaba and Tsuyoshi Setogawa and Koji Toda and Shigeru Ozaki and Muneteka Shidara",
year = "2012",
month = "3",
day = "1",
doi = "10.1016/j.neures.2011.12.004",
language = "English",
volume = "72",
pages = "214--220",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The influence of passband limitation on the waveform of extracellular action potential

AU - Mizuhiki, Takashi

AU - Inaba, Kiyonori

AU - Setogawa, Tsuyoshi

AU - Toda, Koji

AU - Ozaki, Shigeru

AU - Shidara, Muneteka

PY - 2012/3/1

Y1 - 2012/3/1

N2 - The duration of the extracellular action potential (EAP) in single neuronal recording has often been used as a clue to infer biochemical, physiological or functional substrate of the recorded neurons, e.g. neurochemical type. However, when recording a neuronal activity, the high-pass filter is routinely used to achieve higher signal-to-noise ratio. Signal processing theory predicts that passband limitation stretches the waveform of discrete brief impulse. To examine whether the duration of filtered EAP could be the reliable measure, we investigated the influence of high-pass filter both by simulation and unfiltered unit recording data from monkey dorsal raphe. Consistent with the findings in recent theoretical study, the unfiltered EAPs displayed the sharp wave without following bumps. The duration of unfiltered EAP was not correlated with that of filtered EAP. Thus the duration of original EAP cannot be estimated from filtered EAP. It is needed to reexamine the EAP duration measured for classifying the neurons whose activities were recorded under the passband limitation in the related studies.

AB - The duration of the extracellular action potential (EAP) in single neuronal recording has often been used as a clue to infer biochemical, physiological or functional substrate of the recorded neurons, e.g. neurochemical type. However, when recording a neuronal activity, the high-pass filter is routinely used to achieve higher signal-to-noise ratio. Signal processing theory predicts that passband limitation stretches the waveform of discrete brief impulse. To examine whether the duration of filtered EAP could be the reliable measure, we investigated the influence of high-pass filter both by simulation and unfiltered unit recording data from monkey dorsal raphe. Consistent with the findings in recent theoretical study, the unfiltered EAPs displayed the sharp wave without following bumps. The duration of unfiltered EAP was not correlated with that of filtered EAP. Thus the duration of original EAP cannot be estimated from filtered EAP. It is needed to reexamine the EAP duration measured for classifying the neurons whose activities were recorded under the passband limitation in the related studies.

KW - Averaging

KW - Extracellular action potential

KW - Impulse response

KW - Raphe nucleus

KW - Waveform

UR - http://www.scopus.com/inward/record.url?scp=84856554281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856554281&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2011.12.004

DO - 10.1016/j.neures.2011.12.004

M3 - Article

C2 - 22226855

AN - SCOPUS:84856554281

VL - 72

SP - 214

EP - 220

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 3

ER -