The L1 family (kpnl family) sequence near the 3' end of human β-globin gene may have been derived from an active L1 sequence

Atsushi Fujita, Masahira Hattori, Osamu Takenaka, Yoshiyuki Sakaki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We previously reported that some L1 family (Kpnl family) members are closely associated with the Alu family sequence. To understand the details of the Ll-Alu association, the structure of a Ll-Alu unit downstream from the β-globin gene was compared between human and primates. The results revealed that the L1-Alu-associated sequence was formed by the insertion of the L1 sequence, TBG41, into the 3' poly A tract of the preexisting Alu family sequence. It was estimated that the TβG41 sequence was inserted after the divergence of Old World monkeys and hominoids and before the divergence of orang-utan and common ancestor of other higher hominoids. From the calculation of the mutation rates of L1 sequences, it was suggested that the TβG41 was derived from an active L1 sequence which was able to encode reverse transcriptase-related protein.

Original languageEnglish
Pages (from-to)4007-4020
Number of pages14
JournalNucleic Acids Research
Volume15
Issue number10
DOIs
Publication statusPublished - 1987 May 26
Externally publishedYes

Fingerprint

Alu Elements
Globins
Genes
Cercopithecidae
Gene
Proteins
Poly A
Insertional Mutagenesis
RNA-Directed DNA Polymerase
Mutation Rate
Primates
Divergence
Family
Human
Insertion
Reverse
Mutation
Protein
Unit

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

The L1 family (kpnl family) sequence near the 3' end of human β-globin gene may have been derived from an active L1 sequence. / Fujita, Atsushi; Hattori, Masahira; Takenaka, Osamu; Sakaki, Yoshiyuki.

In: Nucleic Acids Research, Vol. 15, No. 10, 26.05.1987, p. 4007-4020.

Research output: Contribution to journalArticle

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