Abstract
Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/-) ) and homozygous ((-/-) ) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3(+/-) or Foxo3(-/-) mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3(+/-) , and Foxo3(-/-) mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3(+/-) mice contrast with those in Foxo1(+/-) mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.
| Original language | English |
|---|---|
| Pages (from-to) | 707-709 |
| Number of pages | 3 |
| Journal | Aging Cell |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 Aug 1 |
| Externally published | Yes |
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Keywords
- cancer
- dietary restriction
- Foxo
- lifespan
- longevity
- mouse
ASJC Scopus subject areas
- Ageing
- Cell Biology
Cite this
The life-extending effect of dietary restriction requires Foxo3 in mice. / Shimokawa, Isao; Komatsu, Toshimitsu; Hayashi, Nobutaka; Kim, Sang Eun; Kawata, Takuya; Park, Seongjoon; Hayashi, Hiroko; Yamaza, Haruyoshi; Chiba, Takuya; Mori, Ryoichi.
In: Aging Cell, Vol. 14, No. 4, 01.08.2015, p. 707-709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The life-extending effect of dietary restriction requires Foxo3 in mice
AU - Shimokawa, Isao
AU - Komatsu, Toshimitsu
AU - Hayashi, Nobutaka
AU - Kim, Sang Eun
AU - Kawata, Takuya
AU - Park, Seongjoon
AU - Hayashi, Hiroko
AU - Yamaza, Haruyoshi
AU - Chiba, Takuya
AU - Mori, Ryoichi
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/-) ) and homozygous ((-/-) ) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3(+/-) or Foxo3(-/-) mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3(+/-) , and Foxo3(-/-) mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3(+/-) mice contrast with those in Foxo1(+/-) mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.
AB - Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/-) ) and homozygous ((-/-) ) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3(+/-) or Foxo3(-/-) mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3(+/-) , and Foxo3(-/-) mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3(+/-) mice contrast with those in Foxo1(+/-) mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.
KW - cancer
KW - dietary restriction
KW - Foxo
KW - lifespan
KW - longevity
KW - mouse
UR - http://www.scopus.com/inward/record.url?scp=84943648496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943648496&partnerID=8YFLogxK
U2 - 10.1111/acel.12340
DO - 10.1111/acel.12340
M3 - Article
C2 - 25808402
AN - SCOPUS:84943648496
VL - 14
SP - 707
EP - 709
JO - Aging Cell
JF - Aging Cell
SN - 1474-9718
IS - 4
ER -