The nucleosome: a powerful regulator of transcription.

A. P. Wolffe, H. Kurumizaka

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Nucleosomes provide the architectural framework for transcription. Histones, DNA elements, and transcription factors are organized into precise regulatory complexes. Positioned nucleosomes can facilitate or impede the transcription process. These structures are dynamic, reflecting the capacity of chromatin to adopt different functional states. Histones are mobile with respect to DNA sequence. Individual histone domains are targeted for posttranslational modifications. Histone acetylation promotes transcription factor access to nucleosomal DNA and relieves inhibitory effects on transcriptional initiation and elongation. The nucleosomal infrastructure emerges as powerful contributor to the regulation of gene activity.

Original languageEnglish
Pages (from-to)379-422
Number of pages44
JournalProgress in Nucleic Acid Research and Molecular Biology
Volume61
Publication statusPublished - 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology

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