The orexigenic effect of GnIH is mediated by central opioid receptors in chicks

Tetsuya Tachibana, Naoto Masuda, Kazuyoshi Tsutsui, Kazuyoshi Ukena, Hiroshi Ueda

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume150
Issue number1
DOIs
Publication statusPublished - 2008 May
Externally publishedYes

Fingerprint

Opioid Receptors
Gonadotropins
Hormones
beta-funaltrexamine
mu Opioid Receptor
Feeding Behavior
Injections
Hypothalamic Hormones
kappa Opioid Receptor
delta Opioid Receptor
Narcotic Antagonists
Nitric Oxide Synthase
Opioid Analgesics
Chickens
Nitric Oxide
Peptides

Keywords

  • Chicks
  • Feeding
  • Gonadotropin-inhibiting hormone
  • Intracerebroventricular injection
  • Opioid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Physiology

Cite this

The orexigenic effect of GnIH is mediated by central opioid receptors in chicks. / Tachibana, Tetsuya; Masuda, Naoto; Tsutsui, Kazuyoshi; Ukena, Kazuyoshi; Ueda, Hiroshi.

In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Vol. 150, No. 1, 05.2008, p. 21-25.

Research output: Contribution to journalArticle

@article{762561e48e284c0492e76ab62ed65bd1,
title = "The orexigenic effect of GnIH is mediated by central opioid receptors in chicks",
abstract = "Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.",
keywords = "Chicks, Feeding, Gonadotropin-inhibiting hormone, Intracerebroventricular injection, Opioid",
author = "Tetsuya Tachibana and Naoto Masuda and Kazuyoshi Tsutsui and Kazuyoshi Ukena and Hiroshi Ueda",
year = "2008",
month = "5",
doi = "10.1016/j.cbpa.2008.02.018",
language = "English",
volume = "150",
pages = "21--25",
journal = "Comparative Biochemistry and Physiology - A Physiology",
issn = "1095-6433",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - The orexigenic effect of GnIH is mediated by central opioid receptors in chicks

AU - Tachibana, Tetsuya

AU - Masuda, Naoto

AU - Tsutsui, Kazuyoshi

AU - Ukena, Kazuyoshi

AU - Ueda, Hiroshi

PY - 2008/5

Y1 - 2008/5

N2 - Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.

AB - Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.

KW - Chicks

KW - Feeding

KW - Gonadotropin-inhibiting hormone

KW - Intracerebroventricular injection

KW - Opioid

UR - http://www.scopus.com/inward/record.url?scp=42749089618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42749089618&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2008.02.018

DO - 10.1016/j.cbpa.2008.02.018

M3 - Article

C2 - 18378171

AN - SCOPUS:42749089618

VL - 150

SP - 21

EP - 25

JO - Comparative Biochemistry and Physiology - A Physiology

JF - Comparative Biochemistry and Physiology - A Physiology

SN - 1095-6433

IS - 1

ER -