The orexigenic effect of GnIH is mediated by central opioid receptors in chicks

Tetsuya Tachibana; Naoto Masuda; Kazuyoshi Tsutsui; Kazuyoshi Ukena; Hiroshi Ueda

doi:10.1016/j.cbpa.2008.02.018

The orexigenic effect of GnIH is mediated by central opioid receptors in chicks

Tetsuya Tachibana, Naoto Masuda, Kazuyoshi Tsutsui, Kazuyoshi Ukena, Hiroshi Ueda

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume	150
Issue number	1
DOIs	https://doi.org/10.1016/j.cbpa.2008.02.018
Publication status	Published - 2008 May
Externally published	Yes

Keywords

Chicks
Feeding
Gonadotropin-inhibiting hormone
Intracerebroventricular injection
Opioid

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Physiology

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title = "The orexigenic effect of GnIH is mediated by central opioid receptors in chicks",

abstract = "Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.",

keywords = "Chicks, Feeding, Gonadotropin-inhibiting hormone, Intracerebroventricular injection, Opioid",

author = "Tetsuya Tachibana and Naoto Masuda and Kazuyoshi Tsutsui and Kazuyoshi Ukena and Hiroshi Ueda",

year = "2008",

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AU - Tachibana, Tetsuya

AU - Masuda, Naoto

AU - Tsutsui, Kazuyoshi

AU - Ukena, Kazuyoshi

AU - Ueda, Hiroshi

PY - 2008/5

Y1 - 2008/5

N2 - Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.

AB - Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.

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