The origin and differentiation of the heteromorphic sex chromosomes Z, W, X, and Y in the frog Rana rugosa, inferred from the sequences of a sex- linked gene, ADP/ATP translocase

Ikuo Miura, Hiromi Ohtani, Masahisa Nakamura, Youko Ichikawa, Kazuo Saitoh

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Sex chromosomes of the Japanese frog Rana rugosa are heteromorphic in the male (XX/XY) or in the female (ZZ/ZW) in two geographic forms, whereas they are still homomorphic in both sexes in two other forms (Hiroshima and Isehara types). To make clear the origin and differentiation mechanisms of the heteromorphic sex chromosomes, we isolated a sex-linked gene, ADP/ATP translocase, and constructed a phylogenetic tree of the genes derived from the sex chromosomes. The tree shows that the Hiroshima gene diverges first, and the rest form two clusters: one includes the Y and Z genes and the other includes the X, W, and Isehara genes. The Hiroshima gene shares more sequence similarity with the Y and Z genes than with the X, W, and Isehara genes. This suggests that the Y and Z sex chromosomes originate from the Hiroshima type, whereas the X and W chromosomes originate from the Isehara-type sex chromosome. Thus, we infer that hybridization between two ancestral forms, with the Hiroshima-type sex chromosome in one and the Isehara-type sex chromosome in the other, was the primary event causing differentiation of the heteromorphic sex chromosomes.

Original languageEnglish
Pages (from-to)1612-1619
Number of pages8
JournalMolecular Biology and Evolution
Volume15
Issue number12
Publication statusPublished - 1998 Dec
Externally publishedYes

Fingerprint

ATP Translocases Mitochondrial ADP
sex linkage
Ranidae
Sex Chromosomes
sex chromosomes
frog
Anura
frogs
chromosome
Genes
gene
genes
W chromosome
Z chromosome
Glandirana rugosa
X Chromosome
X chromosome
Chromosomes
hybridization
phylogenetics

Keywords

  • ADP/ATP translocase
  • Frog
  • Rana rugosa
  • Sex chromosome

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

The origin and differentiation of the heteromorphic sex chromosomes Z, W, X, and Y in the frog Rana rugosa, inferred from the sequences of a sex- linked gene, ADP/ATP translocase. / Miura, Ikuo; Ohtani, Hiromi; Nakamura, Masahisa; Ichikawa, Youko; Saitoh, Kazuo.

In: Molecular Biology and Evolution, Vol. 15, No. 12, 12.1998, p. 1612-1619.

Research output: Contribution to journalArticle

@article{5b5df179975443e3acdb23961d3e71c0,
title = "The origin and differentiation of the heteromorphic sex chromosomes Z, W, X, and Y in the frog Rana rugosa, inferred from the sequences of a sex- linked gene, ADP/ATP translocase",
abstract = "Sex chromosomes of the Japanese frog Rana rugosa are heteromorphic in the male (XX/XY) or in the female (ZZ/ZW) in two geographic forms, whereas they are still homomorphic in both sexes in two other forms (Hiroshima and Isehara types). To make clear the origin and differentiation mechanisms of the heteromorphic sex chromosomes, we isolated a sex-linked gene, ADP/ATP translocase, and constructed a phylogenetic tree of the genes derived from the sex chromosomes. The tree shows that the Hiroshima gene diverges first, and the rest form two clusters: one includes the Y and Z genes and the other includes the X, W, and Isehara genes. The Hiroshima gene shares more sequence similarity with the Y and Z genes than with the X, W, and Isehara genes. This suggests that the Y and Z sex chromosomes originate from the Hiroshima type, whereas the X and W chromosomes originate from the Isehara-type sex chromosome. Thus, we infer that hybridization between two ancestral forms, with the Hiroshima-type sex chromosome in one and the Isehara-type sex chromosome in the other, was the primary event causing differentiation of the heteromorphic sex chromosomes.",
keywords = "ADP/ATP translocase, Frog, Rana rugosa, Sex chromosome",
author = "Ikuo Miura and Hiromi Ohtani and Masahisa Nakamura and Youko Ichikawa and Kazuo Saitoh",
year = "1998",
month = "12",
language = "English",
volume = "15",
pages = "1612--1619",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - The origin and differentiation of the heteromorphic sex chromosomes Z, W, X, and Y in the frog Rana rugosa, inferred from the sequences of a sex- linked gene, ADP/ATP translocase

AU - Miura, Ikuo

AU - Ohtani, Hiromi

AU - Nakamura, Masahisa

AU - Ichikawa, Youko

AU - Saitoh, Kazuo

PY - 1998/12

Y1 - 1998/12

N2 - Sex chromosomes of the Japanese frog Rana rugosa are heteromorphic in the male (XX/XY) or in the female (ZZ/ZW) in two geographic forms, whereas they are still homomorphic in both sexes in two other forms (Hiroshima and Isehara types). To make clear the origin and differentiation mechanisms of the heteromorphic sex chromosomes, we isolated a sex-linked gene, ADP/ATP translocase, and constructed a phylogenetic tree of the genes derived from the sex chromosomes. The tree shows that the Hiroshima gene diverges first, and the rest form two clusters: one includes the Y and Z genes and the other includes the X, W, and Isehara genes. The Hiroshima gene shares more sequence similarity with the Y and Z genes than with the X, W, and Isehara genes. This suggests that the Y and Z sex chromosomes originate from the Hiroshima type, whereas the X and W chromosomes originate from the Isehara-type sex chromosome. Thus, we infer that hybridization between two ancestral forms, with the Hiroshima-type sex chromosome in one and the Isehara-type sex chromosome in the other, was the primary event causing differentiation of the heteromorphic sex chromosomes.

AB - Sex chromosomes of the Japanese frog Rana rugosa are heteromorphic in the male (XX/XY) or in the female (ZZ/ZW) in two geographic forms, whereas they are still homomorphic in both sexes in two other forms (Hiroshima and Isehara types). To make clear the origin and differentiation mechanisms of the heteromorphic sex chromosomes, we isolated a sex-linked gene, ADP/ATP translocase, and constructed a phylogenetic tree of the genes derived from the sex chromosomes. The tree shows that the Hiroshima gene diverges first, and the rest form two clusters: one includes the Y and Z genes and the other includes the X, W, and Isehara genes. The Hiroshima gene shares more sequence similarity with the Y and Z genes than with the X, W, and Isehara genes. This suggests that the Y and Z sex chromosomes originate from the Hiroshima type, whereas the X and W chromosomes originate from the Isehara-type sex chromosome. Thus, we infer that hybridization between two ancestral forms, with the Hiroshima-type sex chromosome in one and the Isehara-type sex chromosome in the other, was the primary event causing differentiation of the heteromorphic sex chromosomes.

KW - ADP/ATP translocase

KW - Frog

KW - Rana rugosa

KW - Sex chromosome

UR - http://www.scopus.com/inward/record.url?scp=0031773526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031773526&partnerID=8YFLogxK

M3 - Article

C2 - 9866197

AN - SCOPUS:0031773526

VL - 15

SP - 1612

EP - 1619

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 12

ER -