Abstract
The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.
| Original language | English |
|---|---|
| Pages (from-to) | 373-381 |
| Number of pages | 9 |
| Journal | Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
| Volume | 344 |
| Issue number | 1310 |
| DOIs | |
| Publication status | Published - 1994 Jun 29 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
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Cite this
May, A. C., Johnson, M. S., Rufino, S. D., Wako, H., Zhu, Z. Y., Sowdhamini, R., Srinivasan, N., Rodionov, M. A., & Blundell, T. L. (1994). The recognition of protein structure and function from sequence: adding value to genome data. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 344(1310), 373-381. https://doi.org/10.1098/rstb.1994.0076