The recognition of protein structure and function from sequence: adding value to genome data.

A. C. May; M. S. Johnson; S. D. Rufino; H. Wako; Z. Y. Zhu; R. Sowdhamini; N. Srinivasan; M. A. Rodionov; T. L. Blundell

doi:10.1098/rstb.1994.0076

The recognition of protein structure and function from sequence: adding value to genome data.

A. C. May, M. S. Johnson, S. D. Rufino, H. Wako, Z. Y. Zhu, R. Sowdhamini, N. Srinivasan, M. A. Rodionov, T. L. Blundell

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.

Original language	English
Pages (from-to)	373-381
Number of pages	9
Journal	Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume	344
Issue number	1310
DOIs	https://doi.org/10.1098/rstb.1994.0076
Publication status	Published - 1994 Jun 29
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

Access to Document

10.1098/rstb.1994.0076

Fingerprint Dive into the research topics of 'The recognition of protein structure and function from sequence: adding value to genome data.'. Together they form a unique fingerprint.

Cite this

May, A. C., Johnson, M. S., Rufino, S. D., Wako, H., Zhu, Z. Y., Sowdhamini, R., Srinivasan, N., Rodionov, M. A., & Blundell, T. L. (1994). The recognition of protein structure and function from sequence: adding value to genome data. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 344(1310), 373-381. https://doi.org/10.1098/rstb.1994.0076

The recognition of protein structure and function from sequence : adding value to genome data. / May, A. C.; Johnson, M. S.; Rufino, S. D.; Wako, H.; Zhu, Z. Y.; Sowdhamini, R.; Srinivasan, N.; Rodionov, M. A.; Blundell, T. L.

In: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 344, No. 1310, 29.06.1994, p. 373-381.

Research output: Contribution to journal › Review article › peer-review

May, AC, Johnson, MS, Rufino, SD, Wako, H, Zhu, ZY, Sowdhamini, R, Srinivasan, N, Rodionov, MA & Blundell, TL 1994, 'The recognition of protein structure and function from sequence: adding value to genome data.', Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol. 344, no. 1310, pp. 373-381. https://doi.org/10.1098/rstb.1994.0076

@article{48da417d0a594b9aa3b7df85c8098bb8,

title = "The recognition of protein structure and function from sequence: adding value to genome data.",

abstract = "The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.",

author = "May, {A. C.} and Johnson, {M. S.} and Rufino, {S. D.} and H. Wako and Zhu, {Z. Y.} and R. Sowdhamini and N. Srinivasan and Rodionov, {M. A.} and Blundell, {T. L.}",

year = "1994",

month = jun,

day = "29",

doi = "10.1098/rstb.1994.0076",

language = "English",

volume = "344",

pages = "373--381",

journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",

issn = "0962-8436",

publisher = "The Royal Society",

number = "1310",

}

TY - JOUR

T1 - The recognition of protein structure and function from sequence

T2 - adding value to genome data.

AU - May, A. C.

AU - Johnson, M. S.

AU - Rufino, S. D.

AU - Wako, H.

AU - Zhu, Z. Y.

AU - Sowdhamini, R.

AU - Srinivasan, N.

AU - Rodionov, M. A.

AU - Blundell, T. L.

PY - 1994/6/29

Y1 - 1994/6/29

N2 - The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.

AB - The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.

UR - http://www.scopus.com/inward/record.url?scp=0028782099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028782099&partnerID=8YFLogxK

U2 - 10.1098/rstb.1994.0076

DO - 10.1098/rstb.1994.0076

M3 - Review article

C2 - 7800707

AN - SCOPUS:0028782099

VL - 344

SP - 373

EP - 381

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0962-8436

IS - 1310

ER -