The recognition of protein structure and function from sequence: adding value to genome data.

A. C. May; M. S. Johnson; S. D. Rufino; H. Wako; Z. Y. Zhu; R. Sowdhamini; N. Srinivasan; M. A. Rodionov; T. L. Blundell

doi:10.1098/rstb.1994.0076

The recognition of protein structure and function from sequence: adding value to genome data.

A. C. May^*, M. S. Johnson, S. D. Rufino, H. Wako, Z. Y. Zhu, R. Sowdhamini, N. Srinivasan, M. A. Rodionov, T. L. Blundell

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.

Original language	English
Pages (from-to)	373-381
Number of pages	9
Journal	Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume	344
Issue number	1310
DOIs	https://doi.org/10.1098/rstb.1994.0076
Publication status	Published - 1994 Jun 29
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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10.1098/rstb.1994.0076

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May, A. C., Johnson, M. S., Rufino, S. D., Wako, H., Zhu, Z. Y., Sowdhamini, R., Srinivasan, N., Rodionov, M. A., & Blundell, T. L. (1994). The recognition of protein structure and function from sequence: adding value to genome data. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 344(1310), 373-381. https://doi.org/10.1098/rstb.1994.0076

May, AC, Johnson, MS, Rufino, SD, Wako, H, Zhu, ZY, Sowdhamini, R, Srinivasan, N, Rodionov, MA & Blundell, TL 1994, 'The recognition of protein structure and function from sequence: adding value to genome data.', Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol. 344, no. 1310, pp. 373-381. https://doi.org/10.1098/rstb.1994.0076

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The recognition of protein structure and function from sequence: adding value to genome data.

Abstract

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