The role of central noradrenergic neurons in electroconvulsive shock-induced muricide inhibition in olfactory bulbectomized rats

Liou Shyh Yuh, Shigenobu Shibata, Ueki Showa

Research output: Contribution to journalArticle

Abstract

In order to elucidate the role of central monoaminergic neurons in electroconvulsive shock (ECS)-induced muricide inhibition in the olfactory bulbectomized rat (OB rat), we examined the effect of chemical or electrical lesions of each monoamine-containing neuron on ECS-induced muricide inhibition. ECS-induced muricide inhibition was antagonized by 6-hydroxydopamine (6-OHDA) treatment and locus coeruleus lesions, while it was unaffected by desipramine + 6-OHDA, substantia nigra lesion, and desipramine + 5,7-dihydroxytryptamine. The present results strongly suggest that ECS-induced muricide inhibition of the OB rat is due to increased activity of the noradrenaline but not of dopamine and serotonin neurons.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume23
Issue number1
DOIs
Publication statusPublished - 1985
Externally publishedYes

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Keywords

  • 6-Hydroxydopamine
  • Central noradrenergic neuron
  • Electroconvulsive shock
  • Muricide
  • Olfactory bulbectomy

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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