The role of circadian rhythms in muscular and osseous physiology and their regulation by nutrition and exercise

Shinya Aoyama, Shigenobu Shibata

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.

Original languageEnglish
Article number63
JournalFrontiers in Neuroscience
Volume11
Issue numberFEB
DOIs
Publication statusPublished - 2017 Feb 14

Fingerprint

Circadian Clocks
Circadian Rhythm
Suprachiasmatic Nucleus
Skeletal Muscle
Homeostasis
Bone and Bones
Photic Stimulation
Hypothalamus
Cues
Genes
Therapeutics

Keywords

  • Bone
  • Chrono-exercise
  • Chrono-nutrition
  • Circadian rhythm
  • Clock gene
  • Skeletal muscle

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The role of circadian rhythms in muscular and osseous physiology and their regulation by nutrition and exercise. / Aoyama, Shinya; Shibata, Shigenobu.

In: Frontiers in Neuroscience, Vol. 11, No. FEB, 63, 14.02.2017.

Research output: Contribution to journalReview article

@article{dad404fe70414b299437731767405a33,
title = "The role of circadian rhythms in muscular and osseous physiology and their regulation by nutrition and exercise",
abstract = "The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.",
keywords = "Bone, Chrono-exercise, Chrono-nutrition, Circadian rhythm, Clock gene, Skeletal muscle",
author = "Shinya Aoyama and Shigenobu Shibata",
year = "2017",
month = "2",
day = "14",
doi = "10.3389/fnins.2017.00063",
language = "English",
volume = "11",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "FEB",

}

TY - JOUR

T1 - The role of circadian rhythms in muscular and osseous physiology and their regulation by nutrition and exercise

AU - Aoyama, Shinya

AU - Shibata, Shigenobu

PY - 2017/2/14

Y1 - 2017/2/14

N2 - The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.

AB - The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.

KW - Bone

KW - Chrono-exercise

KW - Chrono-nutrition

KW - Circadian rhythm

KW - Clock gene

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85014410580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014410580&partnerID=8YFLogxK

U2 - 10.3389/fnins.2017.00063

DO - 10.3389/fnins.2017.00063

M3 - Review article

AN - SCOPUS:85014410580

VL - 11

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - FEB

M1 - 63

ER -