The role of Clock in the plasticity of circadian entrainment

Ryuta Udo, Toshiyuki Hamada, Kazumasa Horikawa, Eiko Iwahana, Kazuko Miyakawa, Kuniaki Otsuka, Shigenobu Shibata

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The mammalian circadian clock lying in suprachiasmatic nucleus (SCN) is synchronized to about 24h by the environmental light-dark cycle (LD). The circadian clock exhibits limits of entrainment above and below 24h, beyond which it will not entrain. Little is known about the mechanisms regulating the limits of entrainment. In this study, we show that wild-type mice entrain to only an LD 24h cycle, whereas Clock mutant mice can entrain to an LD 24, 28, and 32h except for LD 20h and LD 36h cycle. Under an LD 28h cycle, Clock mutant mice showed a clear rhythm in Per2 mRNA expression in the SCN and behavior. Light response was also increased. This is the first report to show that the Clock mutation makes it possible to adapt the circadian oscillator to a long period cycle and indicates that the clock gene may have an important role for the limits of entrainment of the SCN to LD cycle.

    Original languageEnglish
    Pages (from-to)893-898
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume318
    Issue number4
    DOIs
    Publication statusPublished - 2004 Jun 11

    Fingerprint

    Photoperiod
    Plasticity
    Clocks
    Suprachiasmatic Nucleus
    Circadian Clocks
    Genes
    Light
    Messenger RNA
    Mutation

    Keywords

    • Body temperature
    • Circadian rhythm
    • Clock
    • Period 1
    • Period 2
    • Suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    The role of Clock in the plasticity of circadian entrainment. / Udo, Ryuta; Hamada, Toshiyuki; Horikawa, Kazumasa; Iwahana, Eiko; Miyakawa, Kazuko; Otsuka, Kuniaki; Shibata, Shigenobu.

    In: Biochemical and Biophysical Research Communications, Vol. 318, No. 4, 11.06.2004, p. 893-898.

    Research output: Contribution to journalArticle

    Udo, Ryuta ; Hamada, Toshiyuki ; Horikawa, Kazumasa ; Iwahana, Eiko ; Miyakawa, Kazuko ; Otsuka, Kuniaki ; Shibata, Shigenobu. / The role of Clock in the plasticity of circadian entrainment. In: Biochemical and Biophysical Research Communications. 2004 ; Vol. 318, No. 4. pp. 893-898.
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