The role of diastolic pump flow in centrifugal blood pump hemodynamics

Takehide Akimoto, Kenneth N. Litwak, Kenji Yamazaki, Philip Litwak, Shin Ichiro Kihara, Osamu Tagusari, Shun Ich Yamazaki, Marina V. Kameneva, Mary J. Watach, Mitsuo Umezu, Jun Tomioka, Robert L. Kormos, Hitoshi Koyanagi, Bartley P. Griffith

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV-Ao) bypass, and parameters were recorded at different pump speeds under general anesthesia. Pump inflow and outflow pressure, arterial pressure, systemic and pulmonary blood flow, and electrocardiogram (ECG) were recorded on the computer every 5 ms. All parameters were separated into systolic and diastolic components and analyzed. The pulmonary flow was the same as the systemic flow during the study (p > 0.1). Systemic flow consisted of pump flow and LV output through the aortic valve. The ratio of systolic pump flow to pulmonary flow (51.3%) did not change significantly at variable pump speeds (p > 0.1). The other portions of the systemic flow were shared by the left ventricular output and the pump flow during diastole. When pump flow increased during diastole, there was a corresponding decrease in the LV output (Y = -1.068X + 51.462; R∧2 = 0.9501). These show that pump diastolic flow may regulate expansion of the left ventricle in diastole.

    Original languageEnglish
    Pages (from-to)724-727
    Number of pages4
    JournalArtificial Organs
    Volume25
    Issue number9
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Diastole
    Hemodynamics
    Blood
    Pumps
    Lung
    Heart Ventricles
    Systole
    Aortic Valve
    General Anesthesia
    Aorta
    Arterial Pressure
    Japan
    Electrocardiography
    Technology
    Pressure
    Research

    Keywords

    • Centrifugal blood pump
    • Diastolic pump flow
    • Hemodynamics
    • Left ventricular assist device
    • Real-time analysis

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Akimoto, T., Litwak, K. N., Yamazaki, K., Litwak, P., Kihara, S. I., Tagusari, O., ... Griffith, B. P. (2001). The role of diastolic pump flow in centrifugal blood pump hemodynamics. Artificial Organs, 25(9), 724-727. https://doi.org/10.1046/j.1525-1594.2001.06864.x

    The role of diastolic pump flow in centrifugal blood pump hemodynamics. / Akimoto, Takehide; Litwak, Kenneth N.; Yamazaki, Kenji; Litwak, Philip; Kihara, Shin Ichiro; Tagusari, Osamu; Yamazaki, Shun Ich; Kameneva, Marina V.; Watach, Mary J.; Umezu, Mitsuo; Tomioka, Jun; Kormos, Robert L.; Koyanagi, Hitoshi; Griffith, Bartley P.

    In: Artificial Organs, Vol. 25, No. 9, 2001, p. 724-727.

    Research output: Contribution to journalArticle

    Akimoto, T, Litwak, KN, Yamazaki, K, Litwak, P, Kihara, SI, Tagusari, O, Yamazaki, SI, Kameneva, MV, Watach, MJ, Umezu, M, Tomioka, J, Kormos, RL, Koyanagi, H & Griffith, BP 2001, 'The role of diastolic pump flow in centrifugal blood pump hemodynamics', Artificial Organs, vol. 25, no. 9, pp. 724-727. https://doi.org/10.1046/j.1525-1594.2001.06864.x
    Akimoto T, Litwak KN, Yamazaki K, Litwak P, Kihara SI, Tagusari O et al. The role of diastolic pump flow in centrifugal blood pump hemodynamics. Artificial Organs. 2001;25(9):724-727. https://doi.org/10.1046/j.1525-1594.2001.06864.x
    Akimoto, Takehide ; Litwak, Kenneth N. ; Yamazaki, Kenji ; Litwak, Philip ; Kihara, Shin Ichiro ; Tagusari, Osamu ; Yamazaki, Shun Ich ; Kameneva, Marina V. ; Watach, Mary J. ; Umezu, Mitsuo ; Tomioka, Jun ; Kormos, Robert L. ; Koyanagi, Hitoshi ; Griffith, Bartley P. / The role of diastolic pump flow in centrifugal blood pump hemodynamics. In: Artificial Organs. 2001 ; Vol. 25, No. 9. pp. 724-727.
    @article{035fa235fdc24d75923906de23f4534b,
    title = "The role of diastolic pump flow in centrifugal blood pump hemodynamics",
    abstract = "We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV-Ao) bypass, and parameters were recorded at different pump speeds under general anesthesia. Pump inflow and outflow pressure, arterial pressure, systemic and pulmonary blood flow, and electrocardiogram (ECG) were recorded on the computer every 5 ms. All parameters were separated into systolic and diastolic components and analyzed. The pulmonary flow was the same as the systemic flow during the study (p > 0.1). Systemic flow consisted of pump flow and LV output through the aortic valve. The ratio of systolic pump flow to pulmonary flow (51.3{\%}) did not change significantly at variable pump speeds (p > 0.1). The other portions of the systemic flow were shared by the left ventricular output and the pump flow during diastole. When pump flow increased during diastole, there was a corresponding decrease in the LV output (Y = -1.068X + 51.462; R∧2 = 0.9501). These show that pump diastolic flow may regulate expansion of the left ventricle in diastole.",
    keywords = "Centrifugal blood pump, Diastolic pump flow, Hemodynamics, Left ventricular assist device, Real-time analysis",
    author = "Takehide Akimoto and Litwak, {Kenneth N.} and Kenji Yamazaki and Philip Litwak and Kihara, {Shin Ichiro} and Osamu Tagusari and Yamazaki, {Shun Ich} and Kameneva, {Marina V.} and Watach, {Mary J.} and Mitsuo Umezu and Jun Tomioka and Kormos, {Robert L.} and Hitoshi Koyanagi and Griffith, {Bartley P.}",
    year = "2001",
    doi = "10.1046/j.1525-1594.2001.06864.x",
    language = "English",
    volume = "25",
    pages = "724--727",
    journal = "Artificial Organs",
    issn = "0160-564X",
    publisher = "Wiley-Blackwell",
    number = "9",

    }

    TY - JOUR

    T1 - The role of diastolic pump flow in centrifugal blood pump hemodynamics

    AU - Akimoto, Takehide

    AU - Litwak, Kenneth N.

    AU - Yamazaki, Kenji

    AU - Litwak, Philip

    AU - Kihara, Shin Ichiro

    AU - Tagusari, Osamu

    AU - Yamazaki, Shun Ich

    AU - Kameneva, Marina V.

    AU - Watach, Mary J.

    AU - Umezu, Mitsuo

    AU - Tomioka, Jun

    AU - Kormos, Robert L.

    AU - Koyanagi, Hitoshi

    AU - Griffith, Bartley P.

    PY - 2001

    Y1 - 2001

    N2 - We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV-Ao) bypass, and parameters were recorded at different pump speeds under general anesthesia. Pump inflow and outflow pressure, arterial pressure, systemic and pulmonary blood flow, and electrocardiogram (ECG) were recorded on the computer every 5 ms. All parameters were separated into systolic and diastolic components and analyzed. The pulmonary flow was the same as the systemic flow during the study (p > 0.1). Systemic flow consisted of pump flow and LV output through the aortic valve. The ratio of systolic pump flow to pulmonary flow (51.3%) did not change significantly at variable pump speeds (p > 0.1). The other portions of the systemic flow were shared by the left ventricular output and the pump flow during diastole. When pump flow increased during diastole, there was a corresponding decrease in the LV output (Y = -1.068X + 51.462; R∧2 = 0.9501). These show that pump diastolic flow may regulate expansion of the left ventricle in diastole.

    AB - We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV-Ao) bypass, and parameters were recorded at different pump speeds under general anesthesia. Pump inflow and outflow pressure, arterial pressure, systemic and pulmonary blood flow, and electrocardiogram (ECG) were recorded on the computer every 5 ms. All parameters were separated into systolic and diastolic components and analyzed. The pulmonary flow was the same as the systemic flow during the study (p > 0.1). Systemic flow consisted of pump flow and LV output through the aortic valve. The ratio of systolic pump flow to pulmonary flow (51.3%) did not change significantly at variable pump speeds (p > 0.1). The other portions of the systemic flow were shared by the left ventricular output and the pump flow during diastole. When pump flow increased during diastole, there was a corresponding decrease in the LV output (Y = -1.068X + 51.462; R∧2 = 0.9501). These show that pump diastolic flow may regulate expansion of the left ventricle in diastole.

    KW - Centrifugal blood pump

    KW - Diastolic pump flow

    KW - Hemodynamics

    KW - Left ventricular assist device

    KW - Real-time analysis

    UR - http://www.scopus.com/inward/record.url?scp=0035162806&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0035162806&partnerID=8YFLogxK

    U2 - 10.1046/j.1525-1594.2001.06864.x

    DO - 10.1046/j.1525-1594.2001.06864.x

    M3 - Article

    C2 - 11722350

    AN - SCOPUS:0035162806

    VL - 25

    SP - 724

    EP - 727

    JO - Artificial Organs

    JF - Artificial Organs

    SN - 0160-564X

    IS - 9

    ER -