The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma, Zoltan Gombos, Matyas Jokai, Istvan Berkes, Masaki Takeda, Tatsuya Mimura, Zsolt Radak, Ferenc Gyori

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

Original languageEnglish
Pages (from-to)405-414
Number of pages10
JournalJournal of Sport and Health Science
Volume9
Issue number5
DOIs
Publication statusPublished - 2020 Sep

Keywords

  • Adaptation
  • Exercise
  • MicroRNA
  • Oxidative damage
  • Reactive oxygen species
  • Redox regulation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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