The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction

Huimei Wang, Arezoo Khoradmehr, Mohammad Jalali, Mohammad Saied Salehi, Kazuyoshi Tsutsui, Mohammad Reza Jafarzadeh Shirazi, Amin Tamadon

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Objective(s): To benefit from reproduction and deal with challenges in the environmental conditions, animals must adapt internal physiology to maximize the reproduction rate. Maladaptive variations in the neurochemical systems and reproductive system can lead to manifestation of several significant mammalian reprocesses, including mammalian ovarian lifespan. RFamide-related peptide (RFRP, Rfrp), mammalian orthologues of gonadotropin-inhibitory hormone (GnIH), which is a regulator to prevent the gonadotropin-releasing hormone (GnRH) neural activity, is known to be related to reproductive traits. This review aimed to summarize recent five-year observations to outline historic insights and novel perspectives into the functions of RFRPs in coding the mammalian reproductive physiology, especially highlight recent advances in the impact on RFRPs in regulating mammalian ovary lifespan. Materials and Methods: We reviewed the recent five-year important findings of RFRP system involved in mammalian ovary development. Data for this review were collected from Google Scholar and PubMed using the RFRP keyword combined with the keywords related to physiological or pathological reproductive functions. Results: Recent discoveries are focused on three major fronts in research on RFRP role in female reproduction including reproductive functions, energy balance, and stress regulation. The roles of RFRPs in various development phases of mammal reproduction including prepuberty, puberty, estrous cycle, pregnancy, milking, menopause, and/or ovarian diseases have been shown. Conclusion: Overall, these recent advances demonstrate that RFRPs serve as critical mediators in mammalian ovarian development.

    Original languageEnglish
    Pages (from-to)1210-1220
    Number of pages11
    JournalIranian Journal of Basic Medical Sciences
    Volume21
    Issue number12
    DOIs
    Publication statusPublished - 2018 Dec 1

    Fingerprint

    Gonadotropins
    Reproduction
    Hormones
    Peptides
    Physiology
    Ovary
    Ovarian Diseases
    Mammals
    RFamide peptide
    arginylphenylalaninamide
    Estrous Cycle
    Energy balance
    Gonadotropin-Releasing Hormone
    Puberty
    Menopause
    PubMed
    Animals
    Pregnancy
    Research

    Keywords

    • Female
    • Gonadotropin-inhibitory-hormone
    • Mammals
    • Reproduction
    • RFamide-related peptide

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Immunology and Microbiology(all)
    • Drug Discovery
    • Clinical Biochemistry

    Cite this

    The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction. / Wang, Huimei; Khoradmehr, Arezoo; Jalali, Mohammad; Salehi, Mohammad Saied; Tsutsui, Kazuyoshi; Shirazi, Mohammad Reza Jafarzadeh; Tamadon, Amin.

    In: Iranian Journal of Basic Medical Sciences, Vol. 21, No. 12, 01.12.2018, p. 1210-1220.

    Research output: Contribution to journalArticle

    Wang, Huimei ; Khoradmehr, Arezoo ; Jalali, Mohammad ; Salehi, Mohammad Saied ; Tsutsui, Kazuyoshi ; Shirazi, Mohammad Reza Jafarzadeh ; Tamadon, Amin. / The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction. In: Iranian Journal of Basic Medical Sciences. 2018 ; Vol. 21, No. 12. pp. 1210-1220.
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    abstract = "Objective(s): To benefit from reproduction and deal with challenges in the environmental conditions, animals must adapt internal physiology to maximize the reproduction rate. Maladaptive variations in the neurochemical systems and reproductive system can lead to manifestation of several significant mammalian reprocesses, including mammalian ovarian lifespan. RFamide-related peptide (RFRP, Rfrp), mammalian orthologues of gonadotropin-inhibitory hormone (GnIH), which is a regulator to prevent the gonadotropin-releasing hormone (GnRH) neural activity, is known to be related to reproductive traits. This review aimed to summarize recent five-year observations to outline historic insights and novel perspectives into the functions of RFRPs in coding the mammalian reproductive physiology, especially highlight recent advances in the impact on RFRPs in regulating mammalian ovary lifespan. Materials and Methods: We reviewed the recent five-year important findings of RFRP system involved in mammalian ovary development. Data for this review were collected from Google Scholar and PubMed using the RFRP keyword combined with the keywords related to physiological or pathological reproductive functions. Results: Recent discoveries are focused on three major fronts in research on RFRP role in female reproduction including reproductive functions, energy balance, and stress regulation. The roles of RFRPs in various development phases of mammal reproduction including prepuberty, puberty, estrous cycle, pregnancy, milking, menopause, and/or ovarian diseases have been shown. Conclusion: Overall, these recent advances demonstrate that RFRPs serve as critical mediators in mammalian ovarian development.",
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    AU - Salehi, Mohammad Saied

    AU - Tsutsui, Kazuyoshi

    AU - Shirazi, Mohammad Reza Jafarzadeh

    AU - Tamadon, Amin

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