The septum as origin of a lordosis-inhibiting influence in female rats

Effect of neural transection

Korehito Yamanouchi, Yasumasa Arai

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The septum as the origin of a lordosis-inhibiting influence in female rats has been studied. Prior to testing, brain surgery was performed. Some rats were given a ventromedial cut (VMC) just above the anterior commissure, other rats, a posterior transverse cut (PC) or a dorsal horizontal cut (DC) just below the corpus callosum, and still other rats, a bilateral ventrolateral cut (VLC) in the ventrolateral septum and the bed nucleus of the stria terminalis (BST). Additionally, castrated females and those with a VLC sham operation served as castrated controls and sham-operated controls, respectively. All rats were given a daily dose of 0.2 μg of estradiol benzoate (EB) for three days and 0.5 mg of progesterone just prior to testing. The castrated controls evidenced no lordotic response. Lordotic activities also were very low in the surgically operated group, with the exception of the VLC rats who demonstrated significantly high lordotic scores following the administration of 0.2 μg of EB. Two further testings, with the EB increased to 0.5 μg, were conducted, the interval between these tests being 2 weeks, and the VLC rats again demonstrated significantly higher lordotic activity than did the other rats. These results suggest that the septum exerts a lordosis-inhibiting influence, and that the ventrolateral outputs play a critical role in sending this inhibitory signal.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalPhysiology and Behavior
Volume48
Issue number2
DOIs
Publication statusPublished - 1990

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Lordosis
Septal Nuclei
Corpus Callosum
Progesterone
Brain

Keywords

  • Cut
  • Forebrain lordosis-inhibiting system
  • Lordosis in female rats
  • Septum

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

The septum as origin of a lordosis-inhibiting influence in female rats : Effect of neural transection. / Yamanouchi, Korehito; Arai, Yasumasa.

In: Physiology and Behavior, Vol. 48, No. 2, 1990, p. 351-355.

Research output: Contribution to journalArticle

Yamanouchi, Korehito ; Arai, Yasumasa. / The septum as origin of a lordosis-inhibiting influence in female rats : Effect of neural transection. In: Physiology and Behavior. 1990 ; Vol. 48, No. 2. pp. 351-355.
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