The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival

T. Odaka, H. Nakamura, S. Masada, T. Hiyoshi, M. Taguchi, Norihiko Kawate, C. Konaka, H. Kato, K. Tsuji

Research output: Contribution to journalArticle

Abstract

To investigate the genetic background of lung cancer patients, HLA-A, -B, -C, -DR and -DQ antigen frequencies were tested in 130 lung cancer patients, 91 of whom were treated by surgery and 39 by chemotherapy and radiotherapy, with 111 normal healthy individuals as controls. The antigens associated with disease susceptibility, which were significantly increased in lung cancer patients, were HLA-Aw33 and -DQw3, while the antigens associated with resistance, which were significantly decreased in those patients, were HLA-Bw67, -Bw4, -Bw6, -DR4, -DRw53 and -DQw4. However, a significant difference was seen only in Bw6 (corrected p < 0.05). The survival data were analyzed by multivariate analysis, using Cox's proportional hazards model. The results showed that the relapse-free rate of resected cases possessing B5 antigen was lower than in resected cases without the B5 antigen, and that the survival rate of unresected cases with DR2 antigen was significantly higher than in unresected cases without the DR2 antigen (p < 0.05). In conclusion, certain HLA antigens may be significantly related to disease susceptibility, relapse and survival in lung cancer patients.

Original languageEnglish
Pages (from-to)1053-1064
Number of pages12
JournalJapanese Journal of Lung Cancer
Volume33
Issue number7
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Histocompatibility Testing
Disease Susceptibility
Lung Neoplasms
Antigens
Recurrence
Survival
HLA-A*33 antigen
HLA-A Antigens
HLA-B Antigens
HLA Antigens
Proportional Hazards Models
Radiotherapy
Multivariate Analysis
Survival Rate
Drug Therapy

Keywords

  • HLA
  • lung cancer
  • major histocompatibility antigen
  • resistant antigen
  • susceptible antigen

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Odaka, T., Nakamura, H., Masada, S., Hiyoshi, T., Taguchi, M., Kawate, N., ... Tsuji, K. (1993). The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival. Japanese Journal of Lung Cancer, 33(7), 1053-1064.

The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival. / Odaka, T.; Nakamura, H.; Masada, S.; Hiyoshi, T.; Taguchi, M.; Kawate, Norihiko; Konaka, C.; Kato, H.; Tsuji, K.

In: Japanese Journal of Lung Cancer, Vol. 33, No. 7, 1993, p. 1053-1064.

Research output: Contribution to journalArticle

Odaka, T, Nakamura, H, Masada, S, Hiyoshi, T, Taguchi, M, Kawate, N, Konaka, C, Kato, H & Tsuji, K 1993, 'The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival', Japanese Journal of Lung Cancer, vol. 33, no. 7, pp. 1053-1064.
Odaka, T. ; Nakamura, H. ; Masada, S. ; Hiyoshi, T. ; Taguchi, M. ; Kawate, Norihiko ; Konaka, C. ; Kato, H. ; Tsuji, K. / The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival. In: Japanese Journal of Lung Cancer. 1993 ; Vol. 33, No. 7. pp. 1053-1064.
@article{1f708258c7c74ffbbd8a3f89d62e379d,
title = "The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival",
abstract = "To investigate the genetic background of lung cancer patients, HLA-A, -B, -C, -DR and -DQ antigen frequencies were tested in 130 lung cancer patients, 91 of whom were treated by surgery and 39 by chemotherapy and radiotherapy, with 111 normal healthy individuals as controls. The antigens associated with disease susceptibility, which were significantly increased in lung cancer patients, were HLA-Aw33 and -DQw3, while the antigens associated with resistance, which were significantly decreased in those patients, were HLA-Bw67, -Bw4, -Bw6, -DR4, -DRw53 and -DQw4. However, a significant difference was seen only in Bw6 (corrected p < 0.05). The survival data were analyzed by multivariate analysis, using Cox's proportional hazards model. The results showed that the relapse-free rate of resected cases possessing B5 antigen was lower than in resected cases without the B5 antigen, and that the survival rate of unresected cases with DR2 antigen was significantly higher than in unresected cases without the DR2 antigen (p < 0.05). In conclusion, certain HLA antigens may be significantly related to disease susceptibility, relapse and survival in lung cancer patients.",
keywords = "HLA, lung cancer, major histocompatibility antigen, resistant antigen, susceptible antigen",
author = "T. Odaka and H. Nakamura and S. Masada and T. Hiyoshi and M. Taguchi and Norihiko Kawate and C. Konaka and H. Kato and K. Tsuji",
year = "1993",
language = "English",
volume = "33",
pages = "1053--1064",
journal = "Japanese Journal of Lung Cancer",
issn = "0386-9628",
publisher = "Japan Lung Cancer Society",
number = "7",

}

TY - JOUR

T1 - The significance of HLA typing in lung cancer patients, in relation to disease susceptibility, relapse and survival

AU - Odaka, T.

AU - Nakamura, H.

AU - Masada, S.

AU - Hiyoshi, T.

AU - Taguchi, M.

AU - Kawate, Norihiko

AU - Konaka, C.

AU - Kato, H.

AU - Tsuji, K.

PY - 1993

Y1 - 1993

N2 - To investigate the genetic background of lung cancer patients, HLA-A, -B, -C, -DR and -DQ antigen frequencies were tested in 130 lung cancer patients, 91 of whom were treated by surgery and 39 by chemotherapy and radiotherapy, with 111 normal healthy individuals as controls. The antigens associated with disease susceptibility, which were significantly increased in lung cancer patients, were HLA-Aw33 and -DQw3, while the antigens associated with resistance, which were significantly decreased in those patients, were HLA-Bw67, -Bw4, -Bw6, -DR4, -DRw53 and -DQw4. However, a significant difference was seen only in Bw6 (corrected p < 0.05). The survival data were analyzed by multivariate analysis, using Cox's proportional hazards model. The results showed that the relapse-free rate of resected cases possessing B5 antigen was lower than in resected cases without the B5 antigen, and that the survival rate of unresected cases with DR2 antigen was significantly higher than in unresected cases without the DR2 antigen (p < 0.05). In conclusion, certain HLA antigens may be significantly related to disease susceptibility, relapse and survival in lung cancer patients.

AB - To investigate the genetic background of lung cancer patients, HLA-A, -B, -C, -DR and -DQ antigen frequencies were tested in 130 lung cancer patients, 91 of whom were treated by surgery and 39 by chemotherapy and radiotherapy, with 111 normal healthy individuals as controls. The antigens associated with disease susceptibility, which were significantly increased in lung cancer patients, were HLA-Aw33 and -DQw3, while the antigens associated with resistance, which were significantly decreased in those patients, were HLA-Bw67, -Bw4, -Bw6, -DR4, -DRw53 and -DQw4. However, a significant difference was seen only in Bw6 (corrected p < 0.05). The survival data were analyzed by multivariate analysis, using Cox's proportional hazards model. The results showed that the relapse-free rate of resected cases possessing B5 antigen was lower than in resected cases without the B5 antigen, and that the survival rate of unresected cases with DR2 antigen was significantly higher than in unresected cases without the DR2 antigen (p < 0.05). In conclusion, certain HLA antigens may be significantly related to disease susceptibility, relapse and survival in lung cancer patients.

KW - HLA

KW - lung cancer

KW - major histocompatibility antigen

KW - resistant antigen

KW - susceptible antigen

UR - http://www.scopus.com/inward/record.url?scp=0027759731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027759731&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 1053

EP - 1064

JO - Japanese Journal of Lung Cancer

JF - Japanese Journal of Lung Cancer

SN - 0386-9628

IS - 7

ER -