The similar mammary tumour potentials in virgins and breeders of SHN mice.

H. Nagasawa, R. Furuichi, S. Sakamoto, K. Yamamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Spontaneous mammary tumour potential was compared between virgins and breeders of a high mammary tumour strain of SHN mice. Virgins were essentially similar to breeders in both the cumulative and the monthly incidences of mammary tumours. DNA synthesizing enzyme activities and the number and the weight of mammary tumours also differed little between groups. While the number of preneoplastic mammary hyperplastic alveolar nodules (HAN) was significantly higher in breeders than in virgins, little difference was observed between groups in the end-bud formation and the duct growth of normal glands and the growth of HAN. These results indicate that in SHN mice virgins have similar mammary tumour potential to breeders, which is much advantageous for practical use of this strain as an animal model for human breast and other types of cancers.

Original languageEnglish
Pages (from-to)631-634
Number of pages4
JournalJikken dobutsu. Experimental animals
Volume42
Issue number4
Publication statusPublished - 1993 Oct
Externally publishedYes

Fingerprint

mammary neoplasms (animal)
Tumors
Breast Neoplasms
mice
breasts
Enzyme activity
Ducts
Growth
Animals
buds
animal models
enzyme activity
Breast
Animal Models
incidence
neoplasms
DNA
Weights and Measures
Incidence
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nagasawa, H., Furuichi, R., Sakamoto, S., & Yamamoto, K. (1993). The similar mammary tumour potentials in virgins and breeders of SHN mice. Jikken dobutsu. Experimental animals, 42(4), 631-634.

The similar mammary tumour potentials in virgins and breeders of SHN mice. / Nagasawa, H.; Furuichi, R.; Sakamoto, S.; Yamamoto, K.

In: Jikken dobutsu. Experimental animals, Vol. 42, No. 4, 10.1993, p. 631-634.

Research output: Contribution to journalArticle

Nagasawa, H, Furuichi, R, Sakamoto, S & Yamamoto, K 1993, 'The similar mammary tumour potentials in virgins and breeders of SHN mice.', Jikken dobutsu. Experimental animals, vol. 42, no. 4, pp. 631-634.
Nagasawa H, Furuichi R, Sakamoto S, Yamamoto K. The similar mammary tumour potentials in virgins and breeders of SHN mice. Jikken dobutsu. Experimental animals. 1993 Oct;42(4):631-634.
Nagasawa, H. ; Furuichi, R. ; Sakamoto, S. ; Yamamoto, K. / The similar mammary tumour potentials in virgins and breeders of SHN mice. In: Jikken dobutsu. Experimental animals. 1993 ; Vol. 42, No. 4. pp. 631-634.
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