The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons

Kenichi Toma, Takuma Kumamoto, Carina Hanashima, Kenichi Toma, Carina Hanashima

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The prevailing view of upper-layer (UL) neurogenesis in the cerebral cortex is that progenitor cells undergo successive rounds of asymmetric cell division that restrict the competence and production of UL neurons later in development. However, the recent discovery of UL fate-committed early progenitors raises an alternative perspective concerning their ontogeny. To investigate the emergence of UL progenitors, we manipulated the timing and extent of cortical neurogenesis in vivo in mice. We demonstrated that UL competence is tightly linked to deep-layer (DL) neurogenesis and that this sequence is determined primarily through derepression of Fezf2 by Foxg1 within a closed transcriptional cascade. We further demonstrated that the sequential acquisition of UL competence requires negative feedback, which is propagated from postmitotic DL neurons. Thus, neocortical progenitors integrate intrinsic and extrinsic cues to generate UL neurons through a system that controls the sequence of DL and UL neurogenesis and to scale the production of intracortical projection neurons based on the availability of their subcortical projection neuron counterparts during cortical development and evolution.

Original languageEnglish
Pages (from-to)13259-13276
Number of pages18
JournalJournal of Neuroscience
Volume34
Issue number39
DOIs
Publication statusPublished - 2014 Sep 24
Externally publishedYes

Fingerprint

Neurogenesis
Neurons
Mental Competency
Asymmetric Cell Division
Cerebral Cortex
Cues
Stem Cells

Keywords

  • Cell fate
  • Evolution
  • Layer projection neuron
  • Neocortex
  • Neurogenesis
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons. / Toma, Kenichi; Kumamoto, Takuma; Hanashima, Carina; Toma, Kenichi; Hanashima, Carina.

In: Journal of Neuroscience, Vol. 34, No. 39, 24.09.2014, p. 13259-13276.

Research output: Contribution to journalArticle

Toma, Kenichi ; Kumamoto, Takuma ; Hanashima, Carina ; Toma, Kenichi ; Hanashima, Carina. / The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 39. pp. 13259-13276.
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