Theoretical design of monofunctional psoralen compounds in photochemotherapy

Ayako Nakata, Takeshi Baba, Hiromi Nakai

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The geometries and electronic structures in the lowest triplet (T 1) states of psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and their monoadducts were studied by performing density functional theory (DFT) calculations. It was shown that the pyrone ring of 8-MOP is cleaved in the T1 state and the cleaved pyrone ring loses the ability to bond to the thymine residue. Therefore, 8-MOP in the open-ring structure does not form a diadduct, which is thought to cause side effects. DFT calculations on 20 kinds of substituted psoralens showed that the cleavage of the pyrone ring in the T1 state can be controlled by substituting an electron-donating group, especially one having a strong electron-donating resonance effect, at the 8-position of psoralen.

Original languageEnglish
Pages (from-to)1341-1349
Number of pages9
JournalBulletin of the Chemical Society of Japan
Volume80
Issue number7
DOIs
Publication statusPublished - 2007 Dec 1

ASJC Scopus subject areas

  • Chemistry(all)

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