Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings

Hajime Okamoto; Tsutomi Nakanishi; Yukiko Nagai; Kyozaburo Takeda; Ikuo Obataya; Hisakazu Mihara; Hiroaki Azehara; Wataru Mizutani

doi:10.1143/jjap.42.676

Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings

Hajime Okamoto^*, Tsutomi Nakanishi, Yukiko Nagai, Kyozaburo Takeda, Ikuo Obataya, Hisakazu Mihara, Hiroaki Azehara, Wataru Mizutani

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

An unusual penta-peptide nanotube was synthesized by a solid-phase method using Fmoc chemistry. This nanotube consists of the natural homo-L-amino acid sequence (cyclo[-(L-Gln)₅]), which is different from the already-known DL-peptide nanotubes having an even number of residues. We also observed the morphology by atomic force microscope (AFM) and found meandering tubular structures on the substrate. This result is consistent with our ab initio energy calculations, which show that the penta-peptide nanorings stabilize by breaking the C₅ symmetry and stack themselves to form a meandering nanotube through the inter-ring hydrogen bonds.

Original language	English
Pages (from-to)	676-679
Number of pages	4
Journal	Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Volume	42
Issue number	2 A
DOIs	https://doi.org/10.1143/jjap.42.676
Publication status	Published - 2003 Feb

Keywords

AFM observations
Ab initio calculations
Amino acid
Cyclic peptide
Peptide synthesis
Protein nanotube

ASJC Scopus subject areas

Engineering(all)
Physics and Astronomy(all)

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10.1143/jjap.42.676

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Okamoto, H., Nakanishi, T., Nagai, Y., Takeda, K., Obataya, I., Mihara, H., Azehara, H., & Mizutani, W. (2003). Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings. Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, 42(2 A), 676-679. https://doi.org/10.1143/jjap.42.676

Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings. / Okamoto, Hajime; Nakanishi, Tsutomi; Nagai, Yukiko et al.

In: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, Vol. 42, No. 2 A, 02.2003, p. 676-679.

Research output: Contribution to journal › Article › peer-review

Okamoto, H, Nakanishi, T, Nagai, Y, Takeda, K, Obataya, I, Mihara, H, Azehara, H & Mizutani, W 2003, 'Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings', Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, vol. 42, no. 2 A, pp. 676-679. https://doi.org/10.1143/jjap.42.676

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abstract = "An unusual penta-peptide nanotube was synthesized by a solid-phase method using Fmoc chemistry. This nanotube consists of the natural homo-L-amino acid sequence (cyclo[-(L-Gln)5]), which is different from the already-known DL-peptide nanotubes having an even number of residues. We also observed the morphology by atomic force microscope (AFM) and found meandering tubular structures on the substrate. This result is consistent with our ab initio energy calculations, which show that the penta-peptide nanorings stabilize by breaking the C5 symmetry and stack themselves to form a meandering nanotube through the inter-ring hydrogen bonds.",

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AU - Takeda, Kyozaburo

AU - Obataya, Ikuo

AU - Mihara, Hisakazu

AU - Azehara, Hiroaki

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Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings

Abstract

Keywords

ASJC Scopus subject areas

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