Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia

Yuri Miyazaki, Kazuaki Taguchi, Keitaro Sou, Hiroshi Watanabe, Yu Ishima, Toshikazu Miyakawa, Hiroaki Mitsuya, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

(Figure Presented). Bone marrow is a key element in the diagnosis of disorders of erythropoiesis, including anemia, and a potential target in their treatment. However, because efficient delivery of diagnostic and therapeutic agents to bone marrow is difficult, such delivery is achieved by administering drugs in large quantities that often have adverse effects. Here, we achieved selective delivery of recombinant human erythropoietin (rHuEPO) to bone marrow, via its encapsulation in liposomes with L-glutamic acid, N-(3-carboxy-1-oxopropyl)-, 1,5-dihexadecyl ester (SA) (liposome-EPO). The result, in a rabbit model of renal anemia, was a beneficial effect on hematopoiesis, better than with rHuEPO alone. Also, we determined that liposome-EPO delivery to bone marrow depended on specific uptake by bone marrow macrophages because of the presence of SA. These results indicate both that liposome-EPO is a new, promising erythropoietin-stimulating agent and that liposomes with SA have potential for diagnostic and therapeutic applications in diseases originating from bone marrow.

Original languageEnglish
Pages (from-to)4238-4248
Number of pages11
JournalMolecular Pharmaceutics
Volume11
Issue number11
DOIs
Publication statusPublished - 2014 Sep 25

Keywords

  • Bone marrow
  • Erythropoietin
  • Liposome
  • Macrophages

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

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  • Cite this

    Miyazaki, Y., Taguchi, K., Sou, K., Watanabe, H., Ishima, Y., Miyakawa, T., Mitsuya, H., Fukagawa, M., Otagiri, M., & Maruyama, T. (2014). Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia. Molecular Pharmaceutics, 11(11), 4238-4248. https://doi.org/10.1021/mp500453a