Thermodynamic implications of high Q10 of thermo-TRP channels in living cells

Etsuro Ito, Yusuke Ikemoto, Tohru Yoshioka

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Abstract

The activity of thermo-transient receptor potential (TRP) channels is highly dependent on temperature, and thus thermo-TRP reactions have a high temperature coefficient Q10. In thermodynamics, a high value of Q10 indicates the existence of a large activation energy (i.e., a large enthalpy) over a short period during the transition process between the closed and open states of the channels. The Gibbs free energy equation shows that a large entropy is required to compensate for this large enthalpy and permit activation of the channels, suggesting a large conformational change of the channels. These large values of enthalpy and entropy seem to be a match for the values of the unfolding process of globular proteins. We outline these thermodynamic issues in thermo-TRPs.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalBiophysics (Japan)
Volume11
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Enthalpy
  • Entropy
  • Q10
  • TRP channel
  • Temperature dependency

ASJC Scopus subject areas

  • Biophysics

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