Thermodynamic Synthesis of Rotaxanes by Imine Exchange

Stuart J. Rowan, J. Fraser Stoddart

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)


(Matrix Presented) By utilizing the dynamic nature of imine bonds, it is possible to construct [2]rotaxanes from a ring and a preformed dumbbell under thermodynamic control. These dynamic [2]rotaxanes, which exhibit reversible supramolecular-like behavior in the presence of appropriate catalysts, can be "fixed" by reduction of their imine bonds.

Original languageEnglish
Pages (from-to)1913-1916
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - 1999 Dec 16
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine


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