Third model of the undulation pump total artificial heart

Yusuke Abe, Tsuneo Chinzei, Takashi Isoyama, Toshiya Ono, Shuichi Mochizuki, Itsuro Saito, Kiyotaka Iwasaki, Mitsuhiko Ishimaru, Atsushi Baba, Akimasa Kouno, Toshinaga Ozeki, Takahiro Tohyama, Kou Imachi

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    The undulation pump is a small, continuous flow displacement type blood pump, and the undulation pump total artificial heart (UPTAH) is a unique, implantable total artificial heart based on this pump. To improve the durability of the UPTAH for investigating long-term pathophysiology with UPTAH, a third model (UPTAH3) has been developed. UPTAH3 was designed to separate the left and right undulation shafts and to be more durable. The undulation pumps were also redesigned. UPTAH3 was implemented with a diameter of 76 mm, width of 78 or 79 mm, total volume of 292 ml, and weight of 620 g. The priming volumes of the left and right pumps are 26 and 21 ml, respectively. The atrial cuffs and outflow cannulae were also redesigned for UPTAH3. The maximum output against an arterial pressure load of 100 mm Hg is about 11 L/min. The maximum pump efficiency is about 15% in the left pump and 18% in the right pump, giving a maximum total efficiency for both of about 11%. To date, UPTAH3 has been tested in 17 goats, and the longest survival period was 46 days. This third model will be useful for investigating pathophysiology with UPTAH.

    Original languageEnglish
    Pages (from-to)123-127
    Number of pages5
    JournalASAIO Journal
    Volume49
    Issue number1
    DOIs
    Publication statusPublished - 2003 Jan

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    Artificial heart
    Artificial Heart
    Pumps
    Goats
    Arterial Pressure
    Weights and Measures

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Abe, Y., Chinzei, T., Isoyama, T., Ono, T., Mochizuki, S., Saito, I., ... Imachi, K. (2003). Third model of the undulation pump total artificial heart. ASAIO Journal, 49(1), 123-127. https://doi.org/10.1097/00002480-200301000-00020

    Third model of the undulation pump total artificial heart. / Abe, Yusuke; Chinzei, Tsuneo; Isoyama, Takashi; Ono, Toshiya; Mochizuki, Shuichi; Saito, Itsuro; Iwasaki, Kiyotaka; Ishimaru, Mitsuhiko; Baba, Atsushi; Kouno, Akimasa; Ozeki, Toshinaga; Tohyama, Takahiro; Imachi, Kou.

    In: ASAIO Journal, Vol. 49, No. 1, 01.2003, p. 123-127.

    Research output: Contribution to journalArticle

    Abe, Y, Chinzei, T, Isoyama, T, Ono, T, Mochizuki, S, Saito, I, Iwasaki, K, Ishimaru, M, Baba, A, Kouno, A, Ozeki, T, Tohyama, T & Imachi, K 2003, 'Third model of the undulation pump total artificial heart', ASAIO Journal, vol. 49, no. 1, pp. 123-127. https://doi.org/10.1097/00002480-200301000-00020
    Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Saito I et al. Third model of the undulation pump total artificial heart. ASAIO Journal. 2003 Jan;49(1):123-127. https://doi.org/10.1097/00002480-200301000-00020
    Abe, Yusuke ; Chinzei, Tsuneo ; Isoyama, Takashi ; Ono, Toshiya ; Mochizuki, Shuichi ; Saito, Itsuro ; Iwasaki, Kiyotaka ; Ishimaru, Mitsuhiko ; Baba, Atsushi ; Kouno, Akimasa ; Ozeki, Toshinaga ; Tohyama, Takahiro ; Imachi, Kou. / Third model of the undulation pump total artificial heart. In: ASAIO Journal. 2003 ; Vol. 49, No. 1. pp. 123-127.
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