Thoracoscopic cell sheet transplantation with a novel device

Masanori Maeda, Masayuki Yamato, Masato Kanzaki, Hiroshi Iseki, Teruo Okano

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Regenerative medicine with transplantable cell sheets fabricated on temperature-responsive culture surfaces has been successfully achieved in clinical applications, including skin and cornea treatment. Previously, we reported that transplantation of fibroblast cell sheets to wounded lung had big advantages for sealing intraoperative air leaks compared with conventional materials. Here, we report a novel device forminimally invasive transplantation of cell sheets in endoscopic surgery, such as video-assisted thoracoscopic surgery (VATS). The novel device was designed with a computer-aided design (CAD) system, and the three-dimensional (3D) data were transferred to a 3D printer. With this rapid prototyping system, the cell sheet transplantation device was fabricated using a commercially available photopolymer approved for clinical use. Square cell sheets (24x24 mm) were successfully transplanted onto wound sites of porcine lung placed in a human body model, with the device inserted through a 12 mm port. Such a device would enable less invasive transplantation of cell sheets onto a wide variety of internal organs.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume3
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Cell Transplantation
Surgery
3D printers
Photopolymers
Equipment and Supplies
Rapid prototyping
Fibroblasts
Computer aided design
Skin
Cells
Computer-Aided Design
Video-Assisted Thoracic Surgery
Air
Lung
Regenerative Medicine
Human Body
Cornea
Swine
Temperature
Wounds and Injuries

Keywords

  • Cell sheet
  • Minimal invasive surgery
  • Pneumothorax
  • Rapid prototyping system
  • Transplantation
  • Video-assisted thoracoscopic surgery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Cite this

Thoracoscopic cell sheet transplantation with a novel device. / Maeda, Masanori; Yamato, Masayuki; Kanzaki, Masato; Iseki, Hiroshi; Okano, Teruo.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 3, No. 4, 2009, p. 255-259.

Research output: Contribution to journalArticle

Maeda, Masanori ; Yamato, Masayuki ; Kanzaki, Masato ; Iseki, Hiroshi ; Okano, Teruo. / Thoracoscopic cell sheet transplantation with a novel device. In: Journal of Tissue Engineering and Regenerative Medicine. 2009 ; Vol. 3, No. 4. pp. 255-259.
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