Three-dimensional formation of magnetic micro-gel beads for tissue engineering

Hiroyuki Kawamoto

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We have commenced basic research on the three-dimensional pattern formation of micro-gel beads for applications in biological tissue engineering. In this new technique, micro-gel beads are premagnetized by doping them with magnetic nanoparticles. Living cells will be included in beads for actual use. If a nonuniform magnetic field is applied to a solution containing these magnetized beads, the beads will align, contact, and form a 3D structure. The structure is controlled by the seed pattern of the magnetic particles plugged in a substrate and the profile of the magnetic field distribution. We have constructed tubes, which imitate blood vessels, for demonstration using gel beads whose diameters are of the order of several tens of micrometers. The diameter of the demonstrated tube was less than 0.5 mm and its length was 6.6 mm, although living cells were not included in the beads. Numerical calculations by using the discrete element method were conducted to confirm the formation of the tube and to predict the effect of centrifugal force, which will be applied to fill other tissues in the space between magnetically patterned beads. Although this unique technology is in the nascent stage, it can potentially be used to form threedimensional, nonuniform, and heterogeneous artificial organs for tissue engineering.

    Original languageEnglish
    Title of host publicationInternational Conference on Digital Printing Technologies
    Pages476-479
    Number of pages4
    Publication statusPublished - 2008
    EventNIP24: 24th International Conference on Digital Printing Technologies and Digital Fabrication 2007 - Pittsburgh, PA
    Duration: 2008 Sep 62008 Sep 11

    Other

    OtherNIP24: 24th International Conference on Digital Printing Technologies and Digital Fabrication 2007
    CityPittsburgh, PA
    Period08/9/608/9/11

    ASJC Scopus subject areas

    • Media Technology
    • Computer Science Applications

    Fingerprint Dive into the research topics of 'Three-dimensional formation of magnetic micro-gel beads for tissue engineering'. Together they form a unique fingerprint.

    Cite this