Three-dimensional pathological analysis of cerebral aneurysm initiation

Xinning Wang, Kenta Suto, Takanobu Yagi, Koichi Kawamura, Mitsuo Umezu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cerebral aneurysm is known to initiate at the cerebral artery bifurcation. The pathological mechanism of cerebral aneurysm awaits further understanding especially on its initiation. This study sought to elucidate the three-dimensional structure of cerebral vascular bifurcations with and without aneurysms using human cadavers. The two cases had aneurysmal initiations out of total 7 cases. The studied structure was intimal hyperplasia, tunica media and internal elastic lamina, which were recognized by elastica masson staining. The results showed that the non-existence of tunica media and internal elastic lamina was found in the lesion without aneurysm. The non-existence of intimal hyperplasia was only found in the lesion with aneurysm. These data suggest that the formation of intimal hyperplasia may be related with the initiation of aneurysm. We regarded the boundary of existence arteriosclerosis as the position for new arteriosclerosis occurs and thought the direction of new arteriosclerosis grows would influence whether the cerebral aneurysm initiates or not.

Original languageEnglish
Title of host publicationAdvanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings
PublisherSpringer Verlag
Pages95-103
Number of pages9
Volume761
ISBN (Print)9789811063695
DOIs
Publication statusPublished - 2017
EventInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017 - Nanjing, China
Duration: 2017 Sep 222017 Sep 24

Publication series

NameCommunications in Computer and Information Science
Volume761
ISSN (Print)1865-0929

Other

OtherInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017
CountryChina
CityNanjing
Period17/9/2217/9/24

Keywords

  • Cerebral aneurysm
  • Initiation
  • Internal elastic lamina
  • Intimal hyperplasia
  • Tunica media

ASJC Scopus subject areas

  • Computer Science(all)
  • Mathematics(all)

Fingerprint Dive into the research topics of 'Three-dimensional pathological analysis of cerebral aneurysm initiation'. Together they form a unique fingerprint.

  • Cite this

    Wang, X., Suto, K., Yagi, T., Kawamura, K., & Umezu, M. (2017). Three-dimensional pathological analysis of cerebral aneurysm initiation. In Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings (Vol. 761, pp. 95-103). (Communications in Computer and Information Science; Vol. 761). Springer Verlag. https://doi.org/10.1007/978-981-10-6370-1_10