Three-dimensional pattern formation of magnetically labeled microgel beads for biological tissue engineering

Hiroyuki Kawamoto, H. Inoue, M. Nakamura

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    We commenced basic research on the three-dimensional (3D) pattern formation of microgel beads for applications in biological tissue engineering. In this new technique, microgel beads are premagnetized by doping them with magnetic nanoparticles. Living cells will be included in the beads for actual use. If a nonuniform magnetic field is applied to a solution containing these magnetized beads, the beads will align, contact, and form a 3D structure. The structure is controlled by the seed pattern of the magnetic particles plugged in a substrate and the profile of the magnetic field distribution. We constructed tubes, which imitate blood vessels, for demonstration using gel beads whose diameters are of the order of several tens of micrometers. The diameter of the demonstrated tube was less than 0.5 mm and its length was 6.6 mm, although living cells were not included in the beads. Numerical calculations by using the discrete element method were conducted to confirm the formation of the tube and to predict the effect of centrifugal force, which will be applied to fill cells in the space between magnetically patterned beads. Although this unique technology is in the nascent stage, this 3D pattern formation technique by the control of the magnetic field has potential to be one of the effective engineering technologies for manufacturing 3D patterned biological tissues in the future.

    Original languageEnglish
    Article number054701
    JournalJournal of Applied Physics
    Volume105
    Issue number5
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    tissue engineering
    beads
    tubes
    nonuniform magnetic fields
    centrifugal force
    blood vessels
    magnetic fields
    micrometers
    seeds
    manufacturing
    engineering
    gels
    nanoparticles
    profiles
    cells

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

    Cite this

    Three-dimensional pattern formation of magnetically labeled microgel beads for biological tissue engineering. / Kawamoto, Hiroyuki; Inoue, H.; Nakamura, M.

    In: Journal of Applied Physics, Vol. 105, No. 5, 054701, 2009.

    Research output: Contribution to journalArticle

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