Time-dependent effect of glutamate on long-term potentiation in the suprachiasmatic nucleus of rats

Yukiko Nisikawa, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

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10 Citations (Scopus)


The effect of glutamate on optic nerve stimulation-evoked field potentials in rat suprachiasmatic nucleus (SCN) was examined in vitro. Glutamate application for 20 min induced long-term potentiation (LTP) of the field potentials in the SCN at nighttime, whereas that induced a weak LTP at daytime. On the other hand, application for 40 min induced LTP in the SCN during the daytime, whereas it induced a weak one at nighttime. These results indicate that the effect of glutamate is dependent on the application time and that the effect is influenced by the duration of glutamate exposure.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalJapanese Journal of Pharmacology
Issue number2
Publication statusPublished - 2002 Oct 1



  • Glutamate
  • Long-term potentiation
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Pharmacology

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