Time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium

T. Sakaguchi, S. Sakaguchi, Y. Ina, K. Machida

    Research output: Contribution to journalArticle

    Abstract

    Objective: We studied time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium (Be). Material and methods: We analyzed cell populations in spleen of mice, which was injected with 50 μg of Be by a flow-cytometric assay. Results: The percentage of lymphoid cells decreased and the percentages of granulocyte-like cells and macrophage-like cells increased in the mice at the 3rd day after injection (the Be-3 group). Then, the percentages of the CD4-positive cells and the CD8-positive cells were significantly lower and the percentage of the B cells was significantly higher in the Be-3 group than in the untreated mice (the Cont group), Conclusion: The rate of CD4- and CD8-positive cells to B cells in the Be-3 group was significantly lower than that in the Cont group. In our previous paper, we reported that Be promoted the complement and coagulant system at 3 days after injection. These findings suggested that the activity of cellular immunity was suppressed and that of humoral immunity was enhanced at the 3rd day after the Be injection.

    Original languageEnglish
    Pages (from-to)107-111
    Number of pages5
    JournalTrace Elements and Electrocytes
    Volume18
    Issue number3
    Publication statusPublished - 2001

    Keywords

    • B cell
    • Beryllium (Be)
    • CD4-positive cell
    • CD8-positive cell
    • Splenic immunocyte

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology

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