Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

Kento Yamagishi, Izumi Kirino, Isao Takahashi, Hizuru Amano, Shinji Takeoka, Yuji Morimoto, Toshinori Fujie

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Metronomic (that is, low-dose and long-term) photodynamic therapy (mPDT) for treating internal lesions requires the stable fixation of optical devices to internal tissue surfaces to enable continuous, local light delivery. Surgical suturing—the standard choice for device fixation—can be unsuitable in the presence of surrounding major nerves and blood vessels, as well as for organs or tissues that are fragile, change their shape or actively move. Here, we show that an implantable and wirelessly powered mPDT device consisting of near-field-communication-based light-emitting-diode chips and bioadhesive and stretchable polydopamine-modified poly(dimethylsiloxane) nanosheets can be stably fixed onto the inner surface of animal tissue. When implanted subcutaneously in mice with intradermally transplanted tumours, the device led to significant antitumour effects by irradiating for 10 d at approximately 1,000-fold lower intensity than conventional PDT approaches. The mPDT device might facilitate treatment strategies for hard-to-detect microtumours and deeply located lesions that are hard to reach with standard phototherapy.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalNature Biomedical Engineering
DOIs
Publication statusAccepted/In press - 2018 Jul 16

Fingerprint

Tissue Adhesives
Photochemotherapy
Optoelectronic devices
Adhesives
Tissue
Equipment and Supplies
Neoplasms
Photodynamic therapy
Nanosheets
Blood vessels
Polydimethylsiloxane
Optical devices
Light
Optical Devices
Dosimetry
Phototherapy
Light emitting diodes
Tumors
Animals
Blood Vessels

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy. / Yamagishi, Kento; Kirino, Izumi; Takahashi, Isao; Amano, Hizuru; Takeoka, Shinji; Morimoto, Yuji; Fujie, Toshinori.

In: Nature Biomedical Engineering, 16.07.2018, p. 1-10.

Research output: Contribution to journalArticle

Yamagishi, Kento ; Kirino, Izumi ; Takahashi, Isao ; Amano, Hizuru ; Takeoka, Shinji ; Morimoto, Yuji ; Fujie, Toshinori. / Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy. In: Nature Biomedical Engineering. 2018 ; pp. 1-10.
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