Titin and troponin: Central players in the Frank-Starling mechanism of the heart

Norio Fukuda, Takako Terui, Iwao Ohtsuki, Shin'ichi Ishiwata, Satoshi Kurihara

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    The basis of the Frank-Starling mechanism of the heart is the intrinsic ability of cardiac muscle to produce greater active force in response to stretch, a phenomenon known as length-dependent activation. A feedback mechanism transmitted from cross-bridge formation to troponin C to enhance Ca2+ binding has long been proposed to account for length-dependent activation. However, recent advances in muscle physiology research technologies have enabled the identification of other factors involved in length-dependent activation. The striated muscle sarcomere contains a third filament system composed of the giant elastic protein titin, which is responsible for most passive stiffness in the physiological sarcomere length range. Recent studies have revealed a significant coupling of active and passive forces in cardiac muscle, where titin-based passive force promotes cross-bridge recruitment, resulting in greater active force production in response to stretch. More currently, the focus has been placed on the troponin-based "on-off: switching of the thin filament state in the regulation of length-dependent activation. In this review, we discuss how myocardial lengthdependent activation is coordinately regulated by sarcomere proteins.

    Original languageEnglish
    Pages (from-to)119-124
    Number of pages6
    JournalCurrent Cardiology Reviews
    Volume5
    Issue number2
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Connectin
    Starlings
    Sarcomeres
    Troponin
    Myocardium
    Troponin C
    Striated Muscle
    Proteins
    Technology
    Muscles
    Research

    Keywords

    • Calcium
    • Cardiac muscle
    • Connectin

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Titin and troponin : Central players in the Frank-Starling mechanism of the heart. / Fukuda, Norio; Terui, Takako; Ohtsuki, Iwao; Ishiwata, Shin'ichi; Kurihara, Satoshi.

    In: Current Cardiology Reviews, Vol. 5, No. 2, 2009, p. 119-124.

    Research output: Contribution to journalArticle

    Fukuda, N, Terui, T, Ohtsuki, I, Ishiwata, S & Kurihara, S 2009, 'Titin and troponin: Central players in the Frank-Starling mechanism of the heart', Current Cardiology Reviews, vol. 5, no. 2, pp. 119-124. https://doi.org/10.2174/157340309788166714
    Fukuda, Norio ; Terui, Takako ; Ohtsuki, Iwao ; Ishiwata, Shin'ichi ; Kurihara, Satoshi. / Titin and troponin : Central players in the Frank-Starling mechanism of the heart. In: Current Cardiology Reviews. 2009 ; Vol. 5, No. 2. pp. 119-124.
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