TLyP-1-conjugated Au-nanorod@SiO2 core-shell nanoparticles for tumor-targeted drug delivery and photothermal therapy

Baiyao Xu, Yang Ju, Yanbin Cui, Guanbin Song, Yuichi Iwase, Atsushi Hosoi, Yasuyuki Morita

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Mesoporous silica-coated Au nanorod (AuNR@SiO2) is one of the most important appealing nanomaterials for cancer therapy. The multifunctions of chemotherapy, photothermal therapy, and imaging of AuNR@SiO2 make it very useful for cancer therapy. In this study, AuNR@SiO2 was functionalized to deliver hydrophobic antitumor drug and to heat the targeted tumor with the energy of near-infrared (NIR). To carry out the function of targeting the tumor, tLyP-1, a kind of tumor homing and penetrating peptide, was engrafted to AuNR@SiO2. The fabricated AuNR@SiO2-tLyP-1 which was loaded with camptothecin (CPT) showed a robust, selective targeting and penetrating efficiency to Hela and MCF-7 cells and induced the death of these cells. When the micromasses of these AuNR@SiO2-tLyP-1 internalized cells were irradiated by NIR illumination, all the cells were killed instantaneously owing to the increased temperature caused by the surface plasma resonance (SPR) of the internalized AuNR@SiO2-tLyP-1. Moreover, the systematic toxicity of CPT-loaded AuNR@SiO2-tLyP-1 on human mesenchymal stem cells (hMSCs) was minimized, because the AuNR@SiO 2-tLyP-1 selectively targeted and penetrated into the tumor cells, and little hydrophobic CPT was released into the culture medium or blood. This study indicates that the AuNR@SiO2-tLyP-1 drug delivery system (DDS) has great potential application for the chemo-photothermal cancer therapy.

Original languageEnglish
Pages (from-to)7789-7797
Number of pages9
JournalLangmuir
Volume30
Issue number26
DOIs
Publication statusPublished - 2014 Jul 8
Externally publishedYes

Fingerprint

Nanorods
Camptothecin
nanorods
Tumors
therapy
delivery
drugs
tumors
Nanoparticles
nanoparticles
cancer
cells
Cells
homing
Infrared radiation
culture media
plasma resonance
Chemotherapy
stem cells
chemotherapy

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

TLyP-1-conjugated Au-nanorod@SiO2 core-shell nanoparticles for tumor-targeted drug delivery and photothermal therapy. / Xu, Baiyao; Ju, Yang; Cui, Yanbin; Song, Guanbin; Iwase, Yuichi; Hosoi, Atsushi; Morita, Yasuyuki.

In: Langmuir, Vol. 30, No. 26, 08.07.2014, p. 7789-7797.

Research output: Contribution to journalArticle

Xu, Baiyao ; Ju, Yang ; Cui, Yanbin ; Song, Guanbin ; Iwase, Yuichi ; Hosoi, Atsushi ; Morita, Yasuyuki. / TLyP-1-conjugated Au-nanorod@SiO2 core-shell nanoparticles for tumor-targeted drug delivery and photothermal therapy. In: Langmuir. 2014 ; Vol. 30, No. 26. pp. 7789-7797.
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