Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

Nobuhiro Fusetani, Masaki Fujita, Youichi Nakao, Shigeki Matsunaga, Rob W M Van Soest

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng / mL.

Original languageEnglish
Pages (from-to)3397-3402
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number24
Publication statusPublished - 1999 Dec 20
Externally publishedYes

Fingerprint

Theonella
Mirabilis
Cathepsin B
Porifera
Inhibitory Concentration 50
tokaramide A

Keywords

  • Enzyme inhibitors
  • Marine metabolites
  • Natural products
  • Peptides and polypeptides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis. / Fusetani, Nobuhiro; Fujita, Masaki; Nakao, Youichi; Matsunaga, Shigeki; Van Soest, Rob W M.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 24, 20.12.1999, p. 3397-3402.

Research output: Contribution to journalArticle

Fusetani, N, Fujita, M, Nakao, Y, Matsunaga, S & Van Soest, RWM 1999, 'Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis', Bioorganic and Medicinal Chemistry Letters, vol. 9, no. 24, pp. 3397-3402.
Fusetani, Nobuhiro ; Fujita, Masaki ; Nakao, Youichi ; Matsunaga, Shigeki ; Van Soest, Rob W M. / Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 24. pp. 3397-3402.
@article{1dafad99a36f43259e2c8ec5c8921658,
title = "Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis",
abstract = "A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng / mL.",
keywords = "Enzyme inhibitors, Marine metabolites, Natural products, Peptides and polypeptides",
author = "Nobuhiro Fusetani and Masaki Fujita and Youichi Nakao and Shigeki Matsunaga and {Van Soest}, {Rob W M}",
year = "1999",
month = "12",
day = "20",
language = "English",
volume = "9",
pages = "3397--3402",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "24",

}

TY - JOUR

T1 - Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

AU - Fusetani, Nobuhiro

AU - Fujita, Masaki

AU - Nakao, Youichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W M

PY - 1999/12/20

Y1 - 1999/12/20

N2 - A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng / mL.

AB - A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng / mL.

KW - Enzyme inhibitors

KW - Marine metabolites

KW - Natural products

KW - Peptides and polypeptides

UR - http://www.scopus.com/inward/record.url?scp=0033590268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033590268&partnerID=8YFLogxK

M3 - Article

C2 - 10617079

AN - SCOPUS:0033590268

VL - 9

SP - 3397

EP - 3402

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 24

ER -