Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

Nobuhiro Fusetani, Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng / mL.

Original languageEnglish
Pages (from-to)3397-3402
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number24
DOIs
Publication statusPublished - 1999 Dec 20
Externally publishedYes

Keywords

  • Enzyme inhibitors
  • Marine metabolites
  • Natural products
  • Peptides and polypeptides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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