Topo-embryology: DNA evolution from ring to string brings the multi-cellar system

K. Naitoh, H. Inoue, K. Hashimoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

This paper clarifies the reason why microorganisms have ring-like DNA while multi-cell systems have string-like DNA. First, we show the driving force behind the stable morphogenetic process, which is examined in terms of both molecular biology and computational fluid-dynamics. An important point is that the cell-dividing contractile ring shrunk around string-like DNA will form an elliptic curve rather than a perfect circle, because it touches the edge of the string-like DNA, although ring-like DNA induces a circular contractile ring during shrinking. The change in DNA shape determines the shape of a contractile ring after it shrinks. The jet flow generated vertical to the shrinking surface of a contractile ring must also be examined. As the viscosity of water generates the shrinking flow around a contractile ring, the change in the contractile ring shape as it shrinks varies the jet flow inside the cell. The changed flow field carries the next contractile ring to a different displacement. The strong anisotropy of string-like DNA varies the spatial displacement of the next contractile ring generated from the DNA. This scenario corresponds to the fact that the DNA strings of multi-cell systems are displaced on a surface anisotropically in many cases.

Original languageEnglish
Title of host publication6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Pages1163-1166
Number of pages4
DOIs
Publication statusPublished - 2010 Oct 22
Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore
Duration: 2010 Aug 12010 Aug 6

Publication series

NameIFMBE Proceedings
Volume31 IFMBE
ISSN (Print)1680-0737

Conference

Conference6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
CountrySingapore
CitySingapore
Period10/8/110/8/6

Keywords

  • DNA shape
  • cleavage plane
  • contractile ring
  • embryology
  • fluid dynamics

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Naitoh, K., Inoue, H., & Hashimoto, K. (2010). Topo-embryology: DNA evolution from ring to string brings the multi-cellar system. In 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech (pp. 1163-1166). (IFMBE Proceedings; Vol. 31 IFMBE). https://doi.org/10.1007/978-3-642-14515-5_295