Topo-embryology

DNA evolution from ring to string brings the multi-cellar system

Ken Naitoh, H. Inoue, K. Hashimoto

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    6 Citations (Scopus)

    Abstract

    This paper clarifies the reason why microorganisms have ring-like DNA while multi-cell systems have string-like DNA. First, we show the driving force behind the stable morphogenetic process, which is examined in terms of both molecular biology and computational fluid-dynamics. An important point is that the cell-dividing contractile ring shrunk around string-like DNA will form an elliptic curve rather than a perfect circle, because it touches the edge of the string-like DNA, although ring-like DNA induces a circular contractile ring during shrinking. The change in DNA shape determines the shape of a contractile ring after it shrinks. The jet flow generated vertical to the shrinking surface of a contractile ring must also be examined. As the viscosity of water generates the shrinking flow around a contractile ring, the change in the contractile ring shape as it shrinks varies the jet flow inside the cell. The changed flow field carries the next contractile ring to a different displacement. The strong anisotropy of string-like DNA varies the spatial displacement of the next contractile ring generated from the DNA. This scenario corresponds to the fact that the DNA strings of multi-cell systems are displaced on a surface anisotropically in many cases.

    Original languageEnglish
    Title of host publicationIFMBE Proceedings
    Pages1163-1166
    Number of pages4
    Volume31 IFMBE
    DOIs
    Publication statusPublished - 2010
    Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore
    Duration: 2010 Aug 12010 Aug 6

    Other

    Other6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
    CitySingapore
    Period10/8/110/8/6

    Fingerprint

    DNA
    Embryology
    Molecular biology
    Microorganisms
    Flow fields
    Computational fluid dynamics
    Anisotropy
    Viscosity
    Water

    Keywords

    • cleavage plane
    • contractile ring
    • DNA shape
    • embryology
    • fluid dynamics

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Bioengineering

    Cite this

    Naitoh, K., Inoue, H., & Hashimoto, K. (2010). Topo-embryology: DNA evolution from ring to string brings the multi-cellar system. In IFMBE Proceedings (Vol. 31 IFMBE, pp. 1163-1166) https://doi.org/10.1007/978-3-642-14515-5_295

    Topo-embryology : DNA evolution from ring to string brings the multi-cellar system. / Naitoh, Ken; Inoue, H.; Hashimoto, K.

    IFMBE Proceedings. Vol. 31 IFMBE 2010. p. 1163-1166.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Naitoh, K, Inoue, H & Hashimoto, K 2010, Topo-embryology: DNA evolution from ring to string brings the multi-cellar system. in IFMBE Proceedings. vol. 31 IFMBE, pp. 1163-1166, 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech, Singapore, 10/8/1. https://doi.org/10.1007/978-3-642-14515-5_295
    Naitoh, Ken ; Inoue, H. ; Hashimoto, K. / Topo-embryology : DNA evolution from ring to string brings the multi-cellar system. IFMBE Proceedings. Vol. 31 IFMBE 2010. pp. 1163-1166
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