Total syntheses of polyketide-derived bioactive natural products

Kuniaki Tatsuta, Seijiro Hosokawa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Recent progress of total syntheses in our laboratory has been described along with our background and methodologies. The target bioactive polyketides are classified into three categories according to their structures: (i) lactone-fused polycyclic compounds [(+)-cochleamycin A, (+)-tubelactomicin A, and (-)-tetrodecamycin], (ii) aromatic compounds [(-)-tetracycline, (-)-BE-54238B, lymphostin, and (-)-lagunamycin], and (iii) acyclic polyketides [xanthocillin X dimethylether, (+)-trichostatin D, and (+)-actinopyrone A]. Features of the total syntheses are described. Original methodologies have been developed and applied to construct the inherent structures of the target molecules. Most syntheses cited herein are the first total syntheses, and the absolute structures of the target molecules have been determined.

Original languageEnglish
Pages (from-to)217-233
Number of pages17
JournalChemical Record
Volume6
Issue number4
DOIs
Publication statusPublished - 2006 Sep 18

Keywords

  • Natural products
  • Polyketides
  • Synthetic design
  • Synthetic methods
  • Total synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry

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