Total syntheses of polyketide-derived bioactive natural products

Kuniaki Tatsuta, Seijiro Hosokawa

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Recent progress of total syntheses in our laboratory has been described along with our background and methodologies. The target bioactive polyketides are classified into three categories according to their structures: (i) lactone-fused polycyclic compounds [(+)-cochleamycin A, (+)-tubelactomicin A, and (-)-tetrodecamycin], (ii) aromatic compounds [(-)-tetracycline, (-)-BE-54238B, lymphostin, and (-)-lagunamycin], and (iii) acyclic polyketides [xanthocillin X dimethylether, (+)-trichostatin D, and (+)-actinopyrone A]. Features of the total syntheses are described. Original methodologies have been developed and applied to construct the inherent structures of the target molecules. Most syntheses cited herein are the first total syntheses, and the absolute structures of the target molecules have been determined.

    Original languageEnglish
    Pages (from-to)217-233
    Number of pages17
    JournalChemical Record
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - 2006

    Fingerprint

    Polyketides
    Biological Products
    Polycyclic Compounds
    Lactones
    Tetracycline
    Molecules
    Aromatic compounds
    trichostatin D
    cochleamycin A
    xantocillin
    BE 54238B
    actinopyrone A
    lagunamycin
    tubelactomicin A
    tetrodecamycin

    Keywords

    • Natural products
    • Polyketides
    • Synthetic design
    • Synthetic methods
    • Total synthesis

    ASJC Scopus subject areas

    • Chemistry(all)

    Cite this

    Total syntheses of polyketide-derived bioactive natural products. / Tatsuta, Kuniaki; Hosokawa, Seijiro.

    In: Chemical Record, Vol. 6, No. 4, 2006, p. 217-233.

    Research output: Contribution to journalArticle

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