Total syntheses of (-)-scabronines G and A, and (-)-episcabronine A

Yu Kobayakawa, Masahisa Nakada

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Making scab(ronine)s: The total synthesis of (-)-scabronine G features a highly stereoselective oxidative dearomatization/intramolecular inverse-electron-demand Diels-Alder reaction cascade, and the first total synthesis of (-)-scabronine A comprises a highly stereoselective oxa-Michael/protonation/acetalization cascade. The first total synthesis of (-)-episcabronine A includes another highly stereoselective cascade.

    Original languageEnglish
    Pages (from-to)7569-7573
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume52
    Issue number29
    DOIs
    Publication statusPublished - 2013 Jul 15

    Fingerprint

    Protonation
    Electrons
    scabronine G
    scabronine A

    Keywords

    • cycloaddition
    • enantioselectivity
    • medium-ring compounds
    • natural products
    • total synthesis

    ASJC Scopus subject areas

    • Chemistry(all)
    • Catalysis

    Cite this

    Total syntheses of (-)-scabronines G and A, and (-)-episcabronine A. / Kobayakawa, Yu; Nakada, Masahisa.

    In: Angewandte Chemie - International Edition, Vol. 52, No. 29, 15.07.2013, p. 7569-7573.

    Research output: Contribution to journalArticle

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