Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Meng Zhao, Yi Xiao, Satoshi Otsuka, Yoichi Nakao, Yian Guo, Tao Ye

Research output: Contribution to journalArticlepeer-review

Abstract

Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

Original languageEnglish
Article number410
JournalFrontiers in Chemistry
Volume8
DOIs
Publication statusPublished - 2020 May 13

Keywords

  • biological evaluations
  • kakeromamide A
  • marine cyclopeptide
  • structural analogs
  • total synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues'. Together they form a unique fingerprint.

Cite this