@article{7831114534ee436fad3e32e71aa48f4d,
title = "Total synthesis and determination of the absolute configuration of naturally occurring mangromicin A, with potent antitrypanosomal activity",
abstract = "An enantioselective total synthesis of (+)-mangromicin A has been accomplished. The tetrahydrofuran ring of mangromicin A, possessing a tetrasubstituted carbon center, was constructed by Mukaiyama-type vinylogous alkylation via a cyclic oxocarbenium intermediate derived from a γ-hydroxy ketone with ideal stereoselectivity, and the 4-hydroxydihydropyrone scaffold was generated via Dieckmann cyclization at a late stage of the total synthesis. The reliable asymmetric synthesis of (+)-mangromicin A has revealed the absolute configuration of naturally occurring mangromicin A.",
author = "Hirokazu Takada and Takeshi Yamada and Tomoyasu Hirose and Takuma Ishihara and Takuji Nakashima and Yoko Takahashi and Satoshi Omura and Toshiaki Sunazuka",
note = "Funding Information: The authors acknowledge funding from a Grant-in-Aid for Scientific Research C to T.S. (16K08174) and a Grant-in-Aid for Young Scientists B to T.Y. (15K18836) from the Japan Society for the Promotion of Science (JSPS); a KAKENHI Grant; a Grant for Basic Science Research Projects from The Sumitomo Foundation to T.Y. (150705); and an Eisai Award in Synthetic Organic Chemistry, Japan, to T.Y. and a Grant for Doctor 21 to H.T. from the Yoshida Scholarship Foundation. We also thank Dr. Masato Iwatsuki (Kitasato Institute for Life Sciences, Kitasato University) for HPLC and CD analyses. Dr. Kenichiro Nagai and Ms. Noriko Sato (School of Pharmacy, Kitasato University) are acknowledged for analyses of mass and NMR spectra. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2017",
month = jan,
day = "6",
doi = "10.1021/acs.orglett.6b03512",
language = "English",
volume = "19",
pages = "230--233",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "1",
}