Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol

Kana Yamamoto, Robert M. Garbaccio, Shawn J. Stachel, David B. Solit, Gabriela Chiosis, Neal Rosen, Samuel J. Danishefsky

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

A highly convergent synthesis was used to prepare a series of epimers and analogues of radicicol (1). Biological assessment revealed a previously unrecognized correlation between stereochemistry and antitumor potential in these compounds. Significantly, cycloproparadicicol (2) showed promising therapeutic properties based on inhibition of chaperones.

Original languageEnglish
Pages (from-to)1280-1284
Number of pages5
JournalAngewandte Chemie - International Edition
Volume42
Issue number11
DOIs
Publication statusPublished - 2003 Mar 17
Externally publishedYes

Keywords

  • Antitumor agents
  • Chaperone proteins
  • Natural products
  • Structure-activity relationships
  • Synthesis design

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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