Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol

Kana Yamamoto; Robert M. Garbaccio; Shawn J. Stachel; David B. Solit; Gabriela Chiosis; Neal Rosen; Samuel J. Danishefsky

doi:10.1002/anie.200390329

Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol

Kana Yamamoto, Robert M. Garbaccio, Shawn J. Stachel, David B. Solit, Gabriela Chiosis, Neal Rosen, Samuel J. Danishefsky^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

A highly convergent synthesis was used to prepare a series of epimers and analogues of radicicol (1). Biological assessment revealed a previously unrecognized correlation between stereochemistry and antitumor potential in these compounds. Significantly, cycloproparadicicol (2) showed promising therapeutic properties based on inhibition of chaperones.

Original language	English
Pages (from-to)	1280-1284
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	11
DOIs	https://doi.org/10.1002/anie.200390329
Publication status	Published - 2003 Mar 17
Externally published	Yes

Keywords

Antitumor agents
Chaperone proteins
Natural products
Structure-activity relationships
Synthesis design

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200390329

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abstract = "A highly convergent synthesis was used to prepare a series of epimers and analogues of radicicol (1). Biological assessment revealed a previously unrecognized correlation between stereochemistry and antitumor potential in these compounds. Significantly, cycloproparadicicol (2) showed promising therapeutic properties based on inhibition of chaperones.",

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AU - Solit, David B.

AU - Chiosis, Gabriela

AU - Rosen, Neal

AU - Danishefsky, Samuel J.

PY - 2003/3/17

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KW - Chaperone proteins

KW - Natural products

KW - Structure-activity relationships

KW - Synthesis design

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Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol

Abstract

Keywords

ASJC Scopus subject areas

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