Total synthesis of an antitubercular lactone antibiotic, (+)-tubelactomicin A

Seijiro Hosokawa; Masashi Seki; Hisato Fukuda; Kuniaki Tatsuta

doi:10.1016/j.tetlet.2006.01.140

Total synthesis of an antitubercular lactone antibiotic, (+)-tubelactomicin A

Seijiro Hosokawa, Masashi Seki, Hisato Fukuda, Kuniaki Tatsuta

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

(+)-Tubelactomicin A (1), an antitubercular lactone, has been synthesized from (S)-citronellol (2) and 2-deoxy-l-ribonolactone (18) through intramolecular Diels-Alder reaction, Suzuki-Miyaura coupling, and Shiina macrolactonization.

Original language	English
Pages (from-to)	2439-2442
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	14
DOIs	https://doi.org/10.1016/j.tetlet.2006.01.140
Publication status	Published - 2006 Apr 3

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "(+)-Tubelactomicin A (1), an antitubercular lactone, has been synthesized from (S)-citronellol (2) and 2-deoxy-l-ribonolactone (18) through intramolecular Diels-Alder reaction, Suzuki-Miyaura coupling, and Shiina macrolactonization.",

author = "Seijiro Hosokawa and Masashi Seki and Hisato Fukuda and Kuniaki Tatsuta",

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AU - Seki, Masashi

AU - Fukuda, Hisato

AU - Tatsuta, Kuniaki

PY - 2006/4/3

Y1 - 2006/4/3

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AB - (+)-Tubelactomicin A (1), an antitubercular lactone, has been synthesized from (S)-citronellol (2) and 2-deoxy-l-ribonolactone (18) through intramolecular Diels-Alder reaction, Suzuki-Miyaura coupling, and Shiina macrolactonization.

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