Total synthesis of (±)-axinellamines A and B

Daniel P. O'Malley; Junichiro Yamaguchi; Ian S. Young; Ian B. Seiple; Phil S. Baran

doi:10.1002/anie.200801138

Total synthesis of (±)-axinellamines A and B

Daniel P. O'Malley, Junichiro Yamaguchi, Ian S. Young, Ian B. Seiple, Phil S. Baran

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

(Chemical Equation Presented) Chemoselective by design: The first total synthesis of members of the axinellamine/ palau'amine/massadine class of pyrrole-imidazole alkaloids features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.

Original language	English
Pages (from-to)	3581-3583
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	19
DOIs	https://doi.org/10.1002/anie.200801138
Publication status	Published - 2008 Apr 28
Externally published	Yes

Keywords

Alkaloids
Axinellamine
Natural products
Oxidation
Palau'amine
Total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200801138

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author = "O'Malley, {Daniel P.} and Junichiro Yamaguchi and Young, {Ian S.} and Seiple, {Ian B.} and Baran, {Phil S.}",

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AU - Yamaguchi, Junichiro

AU - Young, Ian S.

AU - Seiple, Ian B.

AU - Baran, Phil S.

PY - 2008/4/28

Y1 - 2008/4/28

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KW - Alkaloids

KW - Axinellamine

KW - Natural products

KW - Oxidation

KW - Palau'amine

KW - Total synthesis

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Total synthesis of (±)-axinellamines A and B

Abstract

Keywords

ASJC Scopus subject areas

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