Total synthesis of (±)-axinellamines A and B

Daniel P. O'Malley, Junichiro Yamaguchi, Ian S. Young, Ian B. Seiple, Phil S. Baran

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)


(Chemical Equation Presented) Chemoselective by design: The first total synthesis of members of the axinellamine/ palau'amine/massadine class of pyrrole-imidazole alkaloids features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.

Original languageEnglish
Pages (from-to)3581-3583
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number19
Publication statusPublished - 2008 Apr 28
Externally publishedYes


  • Alkaloids
  • Axinellamine
  • Natural products
  • Oxidation
  • Palau'amine
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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