(Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.
|Number of pages||4|
|Publication status||Published - 2007 Mar 15|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry