A highly stereoselective HfCl4-mediated Diels-Alder reaction of furan and the chiral acrylate ester of Corey's auxiliary to subsequently give 1, and the realization of the postulated biosynthetic pathway for the construction of epoxyquinols A and B, namely, oxidative 6π electrocyclization, followed by Diels-Alder reaction of the unprotected monomer are the key steps in the asymmetric total synthesis of (+)-epoxyquinols A and B.
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2002 Sep 2|
- Asymmetric synthesis
- Diels-Alder reaction
- Total synthesis
ASJC Scopus subject areas