Total synthesis of palau'amine

Ian B. Seiple, Shun Su, Ian S. Young, Chad A. Lewis, Junichiro Yamaguchi, Phil S. Baran

Research output: Contribution to journalArticle

126 Citations (Scopus)


(Figure Presented) Worth the wait: The long anticipated total synthesis of palau'amine has been accomplished by a route featuring highly chemoselective transformations, cascade reactions, and a remarkable transannular cyclization to secure the unprecedented trans-5,5 ring junction (shown in red).

Original languageEnglish
Pages (from-to)1095-1098
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number6
Publication statusPublished - 2010 Feb 1


  • Axinellamines
  • Massadine
  • Palau'amine
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Seiple, I. B., Su, S., Young, I. S., Lewis, C. A., Yamaguchi, J., & Baran, P. S. (2010). Total synthesis of palau'amine. Angewandte Chemie - International Edition, 49(6), 1095-1098.